Associations of Accelerometer-Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study

Kara M Whitaker; Kelley Pettee Gabriel; Matthew P Buman; Mark A Pereira; David R Jacobs Jr; Jared P Reis; Bethany Barone Gibbs; Mercedes R Carnethon; John Staudenmayer; Stephen Sidney; Barbara Sternfeld

doi:10.1161/jaha.118.010212

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Associations of Accelerometer-Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study

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Associations of Accelerometer-Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study

Kara M Whitaker, Kelley Pettee Gabriel, Matthew P Buman, Mark A Pereira, David R Jacobs Jr, Jared P Reis, Bethany Barone Gibbs, Mercedes R Carnethon, John Staudenmayer, Stephen Sidney, …

Journal of the American Heart Association, Vol.8(1), pp.e010212-e010212

01/08/2019

DOI: 10.1161/jaha.118.010212

PMCID: PMC6405708

PMID: 30616480

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Abstract

Background Isotemporal substitution examines the effect on health outcomes of replacing sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity; however, existing studies are limited by cross-sectional study designs. Methods and Results Participants were 1922 adults from the CARDIA (Coronary Artery Risk Development in Young Adults) study. Linear regression examined the associations of sedentary, light-intensity physical activity, and moderate-to-vigorous intensity physical activity at year 20 (2005-2006) with waist circumference, blood pressure, glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and a composite risk score at year 30 (2015-2016). Models then examined change in activity with change in cardiometabolic risk over the same 10-year period. Replacing 30 min/day of sedentary time with 30 min/day of light-intensity physical activity at year 20 was associated with a lower composite risk score (-0.01 SD [95% CI, -0.02, -0.00]) at year 30, characterized by lower waist circumference (0.15 cm [95% CI, -0.27, 0.02]), insulin (0.20 μU/mL [95% CI, -0.35, -0.04]), and higher high-density lipoprotein cholesterol (0.20 mg/dL [95% CI, 0.00, 0.40]; all P<0.05). An increase of 30 min/day in MVPA from year 20 to year 30, when replacing an equivalent increase in sedentary time, was associated with a decrease in the composite risk score (-0.08 [95% CI, -0.13, -0.04]) over the same 10 years, characterized by a decrease in waist circumference (1.52 cm [95% CI, -2.21, -0.84]), insulin (-1.13 μU/mL [95% CI, -1.95, -0.31]), triglycerides (-6.92 mg/dL [95% CI, -11.69, -2.15]), and an increase in high-density lipoprotein cholesterol (1.59 mg/dL [95% CI, 0.45, 2.73]; all P<0.05). Conclusions Replacement of sedentary time with light-intensity physical activity or moderate-to-vigorous intensity physical activity is associated with improved cardiometabolic health 10 years later.

United States - epidemiology

Cardiovascular Diseases - physiopathology

Prospective Studies

Cross-Sectional Studies

Follow-Up Studies

Humans

Risk Factors

Male

Incidence

Young Adult

Time Factors

Adolescent

Cardiovascular Diseases - epidemiology

Adult

Female

Accelerometry - methods

Blood Pressure - physiology

Exercise - physiology

Cardiovascular Diseases - diagnosis

Sedentary Behavior

Details

Title: Subtitle: Associations of Accelerometer-Measured Sedentary Time and Physical Activity With Prospectively Assessed Cardiometabolic Risk Factors: The CARDIA Study
Creators: Kara M Whitaker - 2 Department of Epidemiology College of Public Health University of Iowa Iowa City IA
Kelley Pettee Gabriel - 4 Department of Women's Health Dell Medical School University of Texas at Austin Austin TX
Matthew P Buman - 5 College of Health Solutions Arizona State University Phoenix AZ
Mark A Pereira - 6 Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN
David R Jacobs Jr - 6 Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN
Jared P Reis - 7 Division of Cardiovascular Sciences National Heart, Lung, and Blood Institute Bethesda MD
Bethany Barone Gibbs - 8 Department of Health and Physical Activity University of Pittsburgh PA
Mercedes R Carnethon - 9 Department of Preventive Medicine Feinberg School of Medicine Northwestern University Chicago IL
John Staudenmayer - 10 Department of Mathematics and Statistics University of Massachusetts Amherst MA
Stephen Sidney - 11 Division of Research Kaiser Permanente Northern California Oakland CA
Barbara Sternfeld - 11 Division of Research Kaiser Permanente Northern California Oakland CA
Resource Type: Journal article
Publication Details: Journal of the American Heart Association, Vol.8(1), pp.e010212-e010212
DOI: 10.1161/jaha.118.010212
PMID: 30616480
PMCID: PMC6405708
NLM abbreviation: J Am Heart Assoc
ISSN: 2047-9980
eISSN: 2047-9980
Publisher: England
Grant note: P30 AG024827 / NIA NIH HHS HHSN268201300026C / NHLBI NIH HHS HHSN268201300027C / NHLBI NIH HHS R01 HL078972 / NHLBI NIH HHS HHSN268201300025C / NHLBI NIH HHS HHSN268200900041C / NHLBI NIH HHS HHSN268201300029C / NHLBI NIH HHS R56 HL125423 / NHLBI NIH HHS HHSN268201300028C / NHLBI NIH HHS T32 HL007779 / NHLBI NIH HHS
Language: English
Date published: 01/08/2019
Academic Unit: Epidemiology; Health, Sport, and Human Physiology
Record Identifier: 9984002342702771

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