Journal article
Associations of CCR5, CCR2, and Stromal Cell–Derived Factor 1 Genotypes with Human Immunodeficiency Virus Disease Progression in Patients Receiving Nucleoside Therapy
The Journal of infectious diseases, Vol.184(11), pp.1402-1411
12/01/2001
DOI: 10.1086/324427
PMID: 11709782
Abstract
Genotype data for CCR5, CCR2, and stromal cell–derived factor 1 (SDF-1) were obtained from 354 human immunodeficiency virus type 1 (HIV-1)–positive subjects who were being treated with nucleosides. Associations with HIV-1 load, HIV syncytium-inducing (SI) phenotype, CD4 cell count, and disease progression were analyzed. No differences in HIV-1 load or CD4 cell count were observed between wild type (+) and variant genotypes. Changes from non-SI to SI viral phenotype were more frequent in heterozygotes with a 32-bp deletion (Δ32) in the CCR5 gene than in + homozygotes (40% vs. 7%; P=.01). In a multivariate analysis, heterozygous CCR5 Δ32 was associated with reduced hazard of progression (hazard ratio, 0.32; P=.02). Subjects homozygous for the SDF-1 3′A variant had more-rapid disease progression (P=.008). The SDF-1 homozygous 3′A variant was related to more-rapid disease progression, and CCR5 Δ32 was associated with reduced rates of hazard for disease progression in nucleoside-treated subjects
Details
- Title: Subtitle
- Associations of CCR5, CCR2, and Stromal Cell–Derived Factor 1 Genotypes with Human Immunodeficiency Virus Disease Progression in Patients Receiving Nucleoside Therapy
- Creators
- Janet L Lathey - University of California, San DiegoCamlin Tierney - Harvard UniversitySheng-Yung P Chang - Roche Molecular Systems, Alameda, andRichard T D’Aquila - Massachusetts General HospitalDaniel M Bettendorf - Harvard UniversityHeather C Alexander - Hoffmann-La RocheChristopher D Santini - Roche Molecular Systems, Alameda, andAngela M Hughes - Hoffmann-La RocheCharlene F Barroga - University of California, San DiegoStephen A Spector - University of California, San DiegoJeff E Landes - University of California, San DiegoScott M Hammer - Columbia University
- Contributors
- AIDS Clinical Trials Group 175 Virology TeamJ Brooks Jackson (Contributor) - University of Iowa, Pathology
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.184(11), pp.1402-1411
- Publisher
- The University of Chicago Press
- DOI
- 10.1086/324427
- PMID
- 11709782
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 12/01/2001
- Academic Unit
- Pathology; VPMA - Administration
- Record Identifier
- 9984186503102771
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