Journal article
Associations of D-Dimer with Computed Tomographic Lung Abnormalities, Serum Biomarkers of Lung Injury, and Forced Vital Capacity: MESA Lung Study
Annals of the American Thoracic Society, Vol.18(11), pp.1839-1848
11/2021
DOI: 10.1513/AnnalsATS.202012-1557OC
PMCID: PMC8641831
PMID: 33861685
Abstract
The coagulation cascade may play a role in the pathogenesis of interstitial lung disease through increased production of thrombin and fibrin deposition. Whether circulating coagulation cascade factors are linked to lung inflammation and scarring among community-dwelling adults is unknown.
To test the hypothesis that higher baseline D-dimer concentrations are associated with markers of early lung injury and scarring.
Using the MESA (Multi-Ethnic Study of Atherosclerosis) cohort (
= 6,814), we examined associations of baseline D-dimer concentrations with high attenuation areas from examination 1 (2000-2002;
= 6,184) and interstitial lung abnormalities from examination 5 computed tomographic (CT) scans (2010-2012;
= 2,227), and serum MMP-7 (matrix metalloproteinase-7) and SP-A (surfactant protein-A) from examination 1 (
= 1,098). We examined longitudinal change in forced vital capacity (FVC) from examinations 3-6 (2004-2018,
= 3,562). We used linear logistic regression and linear mixed models to examine associations and adjust for potential confounders.
The mean (standard deviation) age of the cohort was 62 (10) years, and the D-dimer concentration was 0.35 (0.69) ug/ml. For every 10% increase in D-dimer concentration, there was an increase in high attenuation area percentage of 0.27 (95% confidence interval (CI), 0.08-0.47) after adjustment for covariates. Associations were stronger among those older than 65 years (
values for interaction < 0.001). A 10% increase in D-dimer concentration was associated with an odds ratio of 1.05 for interstitial lung abnormalities (95% CI, 0.99-1.11). Higher D-dimer concentrations were associated with higher serum MMP-7 and a faster decline in FVC. D-dimer was not associated with SP-A.
Higher D-dimer concentrations were associated with a greater burden of lung parenchymal abnormalities detected on CT scan, MMP-7, and FVC decline among community-dwelling adults.
Details
- Title: Subtitle
- Associations of D-Dimer with Computed Tomographic Lung Abnormalities, Serum Biomarkers of Lung Injury, and Forced Vital Capacity: MESA Lung Study
- Creators
- John S Kim - University of VirginiaMichaela R Anderson - Department of Medicine.Elana J Bernstein - Department of Medicine.Elizabeth C Oelsner - Department of Medicine.Ganesh Raghu - University of WashingtonImre Noth - University of VirginiaMichael Y Tsai - University of MinnesotaMary Salvatore - Department of Radiology, and.John H M Austin - Department of Radiology, and.Eric A Hoffman - Roy J. and Lucille A. Carver College of MedicineR Graham Barr - Columbia UniversityAnna J Podolanczuk - Department of Medicine, Weill Cornell Medical Center, New York, New York
- Resource Type
- Journal article
- Publication Details
- Annals of the American Thoracic Society, Vol.18(11), pp.1839-1848
- DOI
- 10.1513/AnnalsATS.202012-1557OC
- PMID
- 33861685
- PMCID
- PMC8641831
- ISSN
- 2329-6933
- eISSN
- 2325-6621
- Grant note
- N01HC95169 / NHLBI NIH HHS N01HC95161 / NHLBI NIH HHS N01HC95164 / NHLBI NIH HHS K23 HL150280 / NHLBI NIH HHS N01HC95167 / NHLBI NIH HHS RC1 HL100543 / NHLBI NIH HHS N01HC95159 / NHLBI NIH HHS R03 HL132590 / NHLBI NIH HHS R01 HL103676 / NHLBI NIH HHS N01HC95163 / NHLBI NIH HHS R01 HL077612 / NHLBI NIH HHS N01HC95166 / NHLBI NIH HHS K23 HL130627 / NHLBI NIH HHS UL1 TR001079 / NCATS NIH HHS R01 HL093081 / NHLBI NIH HHS N01HC95160 / NHLBI NIH HHS L30 HL143645 / NHLBI NIH HHS R01 HL157634 / NHLBI NIH HHS K23 HL150301 / NHLBI NIH HHS K23 AR075112 / NIAMS NIH HHS N01HC95168 / NHLBI NIH HHS K23 HL140199 / NHLBI NIH HHS N01HC95165 / NHLBI NIH HHS N01HC95162 / NHLBI NIH HHS R01 HL155576 / NHLBI NIH HHS UL1 TR001420 / NCATS NIH HHS
- Language
- English
- Date published
- 11/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318709302771
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