Journal article
Associations of Dairy Intake with Circulating Biomarkers of Inflammation, Insulin Response, and Dyslipidemia among Postmenopausal Women
Journal of the Academy of Nutrition and Dietetics, Vol.121(10), pp.1984-2002
10/2021
DOI: 10.1016/j.jand.2021.02.029
PMCID: PMC8463409
PMID: 33858777
Abstract
Cardiometabolic diseases are prevalent in aging Americans. Although some studies have implicated greater intake of dairy products, it is not clear how dairy intake is related to biomarkers of cardiometabolic health.
Our aim was to test the hypothesis that associations of dairy foods with biomarkers of lipid metabolism, insulin-like growth factor signaling, and chronic inflammation may provide clues to understanding how dairy can influence cardiometabolic health.
This was a cross-sectional study in the Women's Health Initiative using baseline food frequency questionnaire data to calculate dairy intake.
Participants were 35,352 postmenopausal women aged 50 to 79 years at 40 clinical centers in the United States.
Baseline (1993-1998) concentrations of 20 circulating biomarkers were measured.
Multivariable-adjusted linear regression was used to estimate percent difference in biomarker concentrations per serving of total dairy and individual foods (milk, cheese, yogurt, butter, and low-fat varieties).
Lower triglyceride concentrations were associated with greater intake of total dairy (–0.8% [95% CI –1.2% to –0.3%]), mainly driven by full-fat varieties. Individual dairy foods had specific associations with circulating lipid components. For example, greater total milk intake was associated with lower concentrations of total cholesterol (–0.4% [95% CI –0.7% to –0.2%]) and high-density lipoprotein cholesterol (–0.5% [95% CI –0.9% to –0.1%]), whereas greater butter intake was associated with higher total cholesterol (0.6% [95% CI 0.2% to 1.0%]) and high-density lipoprotein cholesterol (1.6% [95% CI 1.1% to 2.0%]) concentrations. In contrast, higher total yogurt intake was associated with lower total cholesterol (–1.1% [95% CI –2.0% to –0.2%]) and higher high-density lipoprotein cholesterol (1.8% [95% CI 0.5% to 3.1%]). Greater total dairy intake (regardless of fat content), total cheese, full-fat cheese, and yogurt were consistently associated with lower concentrations of glucose, insulin, and C-reactive protein. However, milk and butter were not associated with these biomarkers.
Higher dairy intake, except butter, was associated with a favorable profile of lipids, insulin response, and inflammatory biomarkers, regardless of fat content. Yet, specific dairy foods might influence these markers uniquely. Findings do not support a putative role of dairy in cardiometabolic diseases observed in some previous studies.
Details
- Title: Subtitle
- Associations of Dairy Intake with Circulating Biomarkers of Inflammation, Insulin Response, and Dyslipidemia among Postmenopausal Women
- Creators
- Ni Shi - Department of Internal Medicine, College of Medicine, Comprehensive Cancer Center–James Cancer Hospital, Solove Research Institute, The Ohio State University, Columbus, OHSusan Olivo-Marston - Public Health Honors Program, Division of Epidemiology, College of Public Health, The Ohio State University, ColumbusQi Jin - The Ohio State University, ColumbusDesmond Aroke - Comprehensive Cancer Center–James Cancer Hospital and Solove Research Institute, The Ohio State University, ColumbusJoshua J Joseph - Department of Internal Medicine, College of Medicine, The Ohio State University, ColumbusSteven K Clinton - Department of Internal Medicine, College of Medicine, Comprehensive Cancer Center–James Cancer Hospital, Solove Research Institute, The Ohio State University, Columbus, OHJoAnn E Manson - Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MAKathryn M Rexrode - Division of Women's Health, Department of Medicine, Harvard Medical School, Office for Women's Careers, Center for Diversity and Inclusion, Brigham and Women's Hospital, Boston, MAYasmin Mossavar-Rahmani - Division of Health Behavior Research and Implementation Science, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NYLesley Fels Tinker - Fred Hutchinson Cancer Research Center, North Seattle, WAAladdin H Shadyab - Department of Family Medicine and Public Health, University of California, San Diego School of Medicine, La JollaRhonda S Arthur - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NYLinda G Snetselaar - Department of Epidemiology, College of Public Health, University of Iowa, Iowa CityLinda Van Horn - Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, ILFred K Tabung - Department of Internal Medicine, College of Medicine, Comprehensive Cancer Center–James Cancer Hospital, Solove Research Institute, The Ohio State University, Columbus, OH
- Resource Type
- Journal article
- Publication Details
- Journal of the Academy of Nutrition and Dietetics, Vol.121(10), pp.1984-2002
- DOI
- 10.1016/j.jand.2021.02.029
- PMID
- 33858777
- PMCID
- PMC8463409
- NLM abbreviation
- J Acad Nutr Diet
- ISSN
- 2212-2672
- eISSN
- 2212-2680
- Publisher
- Elsevier Inc
- Grant note
- R00 CA207736; P30 CA016058 / National Cancer Institute (https://doi.org/10.13039/100000054) National Heart, Lung, and Blood Institute (https://doi.org/10.13039/100000050) HHSN268201600018C; HHSN268201600001C; HHSN268201600002C; HHSN268201600003C; HHSN268201600004C / National Institutes of Health (https://doi.org/10.13039/100000002) National Institute of Diabetes and Digestive and Kidney Diseases (https://doi.org/10.13039/100000062)
- Language
- English
- Date published
- 10/2021
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984215048802771
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