Journal article
Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women
The journal of clinical endocrinology and metabolism, Vol.105(4), pp.1126-1136
04/01/2020
DOI: 10.1210/clinem/dgz327
PMCID: 7077951
PMID: 31900485
Abstract
Context: Endogenous sex hormones may be involved in the pathogenesis of cardiovascular disease (CVD) in women. Carotid plaque characteristics, such as echogenicity, an ultrasound measure that reflects plaque composition, may identify unstable plaques that are more likely to rupture, precipitating a CVD event. However, few studies have considered sex steroids in relation to carotid plaque and its characteristics.
Objective: To evaluate estrone (E1), estradiol (E2), testosterone (T), sex hormone binding globulin (SHBG), and free T (FT) in relation to carotid plaque in women.
Design, Setting, and Participants: In MsHeart, a cross-sectional study of 304 women aged 40 to 60 years, participants underwent a carotid artery ultrasound assessment. The current analysis included MsHeart participants with carotid plaque (n = 141, 46%). E1, E2, and T were assayed using liquid chromatography-tandem mass spectrometry; FT was estimated using ensemble allostery models. Regression models were adjusted for sociodemographic characteristics and CVD risk factors.
Main Outcomes: Carotid plaque burden (number of plaques, total plaque area [TPA]) and characteristics (calcification, echogenicity) were determined using semi-automated software.
Results: SHBG was inversely related to TPA (odds ratio [OR] 0.39; 95% confidence interval [CI] 0.21, 0.74; multivariable) and higher FTs were associated with greater TPA (OR 2.89; 95% CI 1.31, 6.37; multivariable). Higher E1 was related to echogenicity (OR 2.31; 95% CI 1.26, 4.33; multivariable), characteristic of more stable plaque.
Conclusions: SHBG and FT are related to TPA while E1 is related to plaque echogenicity, suggesting these hormones have different roles in the development of carotid plaque. Our findings highlight the importance of sex hormones in the development of carotid plaque in midlife women.
Details
- Title: Subtitle
- Associations of Endogenous Sex Hormones with Carotid Plaque Burden and Characteristics in Midlife Women
- Creators
- Yamnia Cortes - University of North Carolina at Chapel HillEmma Barinas-Mitchell - University of PittsburghNatalie Suder Egnot - Greater Pittsburgh Orthopaedic AssociatesShalender Bhasin - Brigham and Women's HospitalRavi Jasuja - Brigham and Women's HospitalNanette Santoro - University of Colorado DenverRebecca C. Thurston - University of Pittsburgh
- Resource Type
- Journal article
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.105(4), pp.1126-1136
- Publisher
- Endocrine Soc
- DOI
- 10.1210/clinem/dgz327
- PMID
- 31900485
- PMCID
- 7077951
- ISSN
- 0021-972X
- eISSN
- 1945-7197
- Number of pages
- 11
- Grant note
- T32HL083825 / National Heart Lung and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) S10RR023461 / University of Pittsburgh Small Molecule Biomarker Core (NIH) P30AG031679 / Boston Claude D. Pepper Older Americans Independence Center from the National Institute on Aging UL1TR000005 / University of Pittsburgh Clinical and Translational Science Institute (NIH) R43AG045011; R44AG045011; R01AG31206 / National Institutes of Health, National Institute on Aging; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) CDC Foundation; United States Department of Health & Human Services; Centers for Disease Control & Prevention - USA R01HL105647; K24123565 / NIH, National Heart Lung and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 04/01/2020
- Academic Unit
- Nursing
- Record Identifier
- 9984446423602771
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