Journal article
Associations of Insulin Resistance With Systolic and Diastolic Blood Pressure A Study From the HCHS/SOL
Hypertension (Dallas, Tex. 1979), Vol.78(3), pp.716-725
09/01/2021
DOI: 10.1161/HYPERTENSIONAHA.120.16905
PMCID: PMC8650976
PMID: 34379440
Abstract
Insulin resistance is hypothesized to contribute to increases in blood pressure (BP) through both the renin-angiotensin-aldosterone and sympathetic nervous systems. Prior large-scale studies examining this association are confounded by overt diabetes, obesity, and antihypertensive medication use. In a cross-sectional analysis of 10 810 HCHS/SOL (Hispanic Community Health Study/Study of Latinos) participants without diabetes and not taking antihypertensive medications, we examined the associations of insulin resistance, quantified by homeostasis model assessment of insulin resistance (HOMA-IR), with systolic BP (SBP) and diastolic BP overall and stratified by sex and prediabetes status in unadjusted and adjusted analyses. The total sample included 52% women; mean (SD) age, 37.2 (13.4) years; 39% of participants had prediabetes (mean [SD] HOMA-IR, 2.8 [2.2]). Stage 1 or 2 hypertension was present in 26% of participants (mean [SD] SBP, 116.8 [15] mm Hg and diastolic BP, 71.0 [10.4] mm Hg). Overall, there was a significant linear association between HOMA-IR and both SBP (beta, 2.64 +/- 0.44) and diastolic BP (beta, 1.49 +/- 0.35). We found a significant interaction with sex and the association between HOMA-IR and SBP; the association was linear in men and nonlinear in women. There was no statistically significant interaction between prediabetes status and the associations between HOMA-IR and BP. In conclusion, in a large community-based sample of Hispanic/Latino adults of diverse national backgrounds not taking antihypertensive medications and free from diabetes, insulin resistance was positively associated with both SBP and diastolic BP. Future longitudinal studies, with adequate power to examine sex-specific differences, are needed to examine the independent contribution of insulin resistance to the development of hypertension.
Details
- Title: Subtitle
- Associations of Insulin Resistance With Systolic and Diastolic Blood Pressure A Study From the HCHS/SOL
- Creators
- Odayme Quesada - Cedars-Sinai Smidt Heart InstituteBrian Claggett - Brigham and Women's HospitalFatima Rodriguez - Stanford UniversityJianwen Cai - University of North Carolina at Chapel HillAshley E. Moncrieft - University of MiamiKarin Garcia - University of MiamiMarina Del Rios Rivera - University of Illinois ChicagoDavid B. Hanna - Albert Einstein College of MedicineMartha L. Daviglus - University of Illinois ChicagoGregory A. Talavera - San Diego State UniversityC. Noel Bairey Merz - Cedars-Sinai Smidt Heart InstituteScott D. Solomon - Brigham and Women's HospitalSusan Cheng - Cedars-Sinai Smidt Heart InstituteNatalie A. Bello - Columbia University Irving Medical Center
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.78(3), pp.716-725
- DOI
- 10.1161/HYPERTENSIONAHA.120.16905
- PMID
- 34379440
- PMCID
- PMC8650976
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 10
- Grant note
- Erika J. Glazer Women's Heart Research Initiative HHSN268201300001I/N01-HC-65233; HHSN268201300004I/N01HC-65234; HHSN268201300002I/N01-HC-65235; HHSN268201300003I/N01-HC-65236; HHSN268201300005I/N01-HC-65237 / National Heart, Lung, and Blood Institute (NHLBI); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) T32HL116273; K23HL151867 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA K23-HL136853; R01HL153382; R00-HL-107642; K01 HL144607; K01-HL-137557 / NIH/NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Linda Joy Pollin Women's Heart Health Program National Institutes of Health (NIH) Office of Dietary Supplements; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) National Institute of Dental and Craniofacial Research; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Dental & Craniofacial Research (NIDCR) National Institute on Minority Health and Health Disparities; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Minority Health & Health Disparities (NIMHD) National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Barbra Streisand Women's Cardiovascular Research and Education Program National Institute on Deafness and Other Communication Disorders; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD) Ellison Foundation; Lawrence Ellison Foundation
- Language
- English
- Date published
- 09/01/2021
- Academic Unit
- Emergency Medicine
- Record Identifier
- 9984297140002771
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