Journal article
Associations of Insulin and IGFBP-3 with Lung Cancer Susceptibility in Current Smokers
JNCI : Journal of the National Cancer Institute, Vol.108(7), p.djw012
07/2016
DOI: 10.1093/jnci/djw012
PMCID: PMC5929107
PMID: 27071409
Abstract
The epidermal growth factor receptor (EGFR) signaling network is involved in lung carcinogenesis. This study examined whether ligands that activate or suppress the EGFR signaling network were associated with lung cancer risk in ever smokers.
A nested case-control study within the Women's Health Initiative assessed baseline plasma levels of insulin, insulin-like growth factor (IGF)-1, insulin-like growth factor binding protein (IGFBP)-3, interleukin (IL)-6, hepatocyte growth factor (HGF), and nerve growth factor (NGF) in 1143 ever-smoking lung cancer cases and 1143 controls. Leptin was measured as an adiposity biomarker. Conditional logistic regression was used in data analyses.
Leptin was inversely associated with lung cancer risk (odds ratio [ORcontinuous] per Ln [pg/mL] = 0.85, 95% confidence interval [CI] = 0.74 to 0.98). After adjusting for adiposity and other risk factors, null associations were found for IL-6, HGF, and NGF. In current smokers, but not former smokers, high insulin levels were associated with increased lung cancer risk (OR for 4th quartile vs others [ORq4] = 2.06, 95% CI = 1.30 to 3.26) whereas IGFBP-3 had a linear inverse association (ORcontinuous per μg/mL = 0.64, 95% CI = 0.41 to 0.98). The insulin association was consistent across subgroups defined by body mass index and histological type, but the IGFBP-3 association was specific to small cell lung cancer. There was a modest positive association between IGF-1 and lung cancer risk in current smokers (ORq4 = 1.44, 95% CI = 0.90 to 2.29).
Independent of obesity, high insulin levels but reduced levels of IGFBP-3 were associated with increased lung cancer risk in current smokers.
Details
- Title: Subtitle
- Associations of Insulin and IGFBP-3 with Lung Cancer Susceptibility in Current Smokers
- Creators
- Gloria Y F Ho - Northwell HealthSiqun L Zheng - Wake Forest UniversityMary Cushman - University of VermontRoman Perez-Soler - Yeshiva UniversityMimi Kim - London School of Hygiene & Tropical MedicineXiaonan Xue - London School of Hygiene & Tropical MedicineTao Wang - London School of Hygiene & Tropical MedicineNicolas F Schlecht - London School of Hygiene & Tropical MedicineLesley Tinker - Fred Hutch Cancer CenterThomas E Rohan - London School of Hygiene & Tropical MedicineSylvia Wassertheil-Smoller - Yeshiva UniversityRobert Wallace - University of IowaChu Chen - Fred Hutch Cancer CenterJianfeng Xu - NorthShore University HealthSystemHerbert Yu - University of Hawaiʻi at Mānoa
- Resource Type
- Journal article
- Publication Details
- JNCI : Journal of the National Cancer Institute, Vol.108(7), p.djw012
- DOI
- 10.1093/jnci/djw012
- PMID
- 27071409
- PMCID
- PMC5929107
- NLM abbreviation
- J Natl Cancer Inst
- ISSN
- 0027-8874
- eISSN
- 1460-2105
- Grant note
- P30 CA086862 / NCI NIH HHS R01 CA143597 / NCI NIH HHS
- Language
- English
- Date published
- 07/2016
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363637202771
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