Journal article
Associations of Maternal Weight Status Before, During, and After Pregnancy with Inflammatory Markers in Breast Milk
Obesity (Silver Spring, Md.), Vol.25(12), pp.2092-2099
12/2017
DOI: 10.1002/oby.22025
PMCID: PMC5705414
PMID: 28985033
Abstract
The goal of this study was to examine the associations of maternal weight status before, during, and after pregnancy with breast milk C-reactive protein (CRP) and interleukin 6 (IL-6), two bioactive markers of inflammation, measured at 1 and 3 months post partum.
Participants were 134 exclusively breastfeeding mother-infant dyads taking part in the Mothers and Infants Linked for Health (MILK) study, who provided breast milk samples. Pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) were assessed by chart abstraction; postpartum weight loss was measured at the 1- and 3-month study visits. Linear regression was used to examine the associations of maternal weight status with repeated measures of breast milk CRP and IL-6 at 1 and 3 months, after adjustment for potential confounders.
Pre-pregnancy BMI and excessive GWG, but not total GWG or postpartum weight loss, were independently associated with breast milk CRP after adjustment (β = 0.49, P < 0.001 and β = 0.51, P = 0.011, respectively). No associations were observed for IL-6.
High pre-pregnancy BMI and excessive GWG are associated with elevated levels of breast milk CRP. The consequences of infants receiving varying concentrations of breast milk inflammatory markers are unknown; however, it is speculated that there are implications for the intergenerational transmission of disease risk.
Details
- Title: Subtitle
- Associations of Maternal Weight Status Before, During, and After Pregnancy with Inflammatory Markers in Breast Milk
- Creators
- Kara M Whitaker - Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USARegina C Marino - Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USAJacob L Haapala - Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USALaurie Foster - Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USAKaty D Smith - Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USAApril M Teague - Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USADavid R Jacobs - Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USAPatricia L Fontaine - Health Partners Institute for Education and Research, Minneapolis, Minnesota, USAPatricia M McGovern - Division of Environmental Health Sciences, University of Minnesota, Minneapolis, Minnesota, USATonya C Schoenfuss - Department of Food Science and Nutrition, University of Minnesota, Minneapolis, Minnesota, USALisa Harnack - Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USADavid A Fields - Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USAEllen W Demerath - Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA
- Resource Type
- Journal article
- Publication Details
- Obesity (Silver Spring, Md.), Vol.25(12), pp.2092-2099
- Publisher
- United States
- DOI
- 10.1002/oby.22025
- PMID
- 28985033
- PMCID
- PMC5705414
- ISSN
- 1930-7381
- eISSN
- 1930-739X
- Grant note
- R01 HD080444 / NICHD NIH HHS T32 HL007779 / NHLBI NIH HHS
- Language
- English
- Date published
- 12/2017
- Academic Unit
- Epidemiology; Health and Human Physiology
- Record Identifier
- 9984002416002771
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