Journal article
Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities
American journal of respiratory and critical care medicine, Vol.205(7), pp.795-805
04/01/2022
DOI: 10.1164/rccm.202108-1967OC
PMCID: PMC10394677
PMID: 34929108
Abstract
Rationale: Higher blood monocyte counts are associated with worse survival in adults with clinically diagnosed pulmonary fibrosis. Their association with the development and progression of interstitial lung abnormalities (ILA) in humans is unknown.
Objectives: We evaluated the associations of blood monocyte count, and other immune cell types, with ILA, high-attenuation areas, and FVC in four independent cohorts.
Methods: We included participants with measured monocyte counts and computed tomographic (CT) imaging enrolled in MESA (Multi-Ethnic Study of Atherosclerosis, n = 484), AGES-Reykjavik (Age/Gene Environment Susceptibility Study, n = 3,547), COPDGene (Genetic Epidemiology of COPD, n = 2,719), and the ECLIPSE (Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points, n = 646).
Measurements and Main Results: After adjustment for covariates, a 1-SD increment in blood monocyte count was associated with ILA in MESA (odds ratio [OR], 1.3; 95% confidence interval [CI], 1.0-1.8), AGES-Reykjavik (OR, 1.2; 95% CI, 1.1-1.3), COPDGene (OR, 1.3; 95% CI, 1.2-1.4), and ECLIPSE (OR, 1.2; 95% CI, 1.0-1.4). A higher monocyte count was associated with ILA progression over 5 years in AGESReykjavik (OR, 1.2; 95% CI, 1.0-1.3). Compared with participants without ILA, there was a higher percentage of activated monocytes among those with ILA in MESA. Higher monocyte count was associated with greater high-attenuation areas in MESA and lower FVC in MESA and COPDGene. Associations of other immune cell types were less consistent.
Conclusions: Higher blood monocyte counts were associated with the presence and progression of interstitial lung abnormalities and lower FVC.
Details
- Title: Subtitle
- Associations of Monocyte Count and Other Immune Cell Types with Interstitial Lung Abnormalities
- Creators
- John S. Kim - Columbia UniversityGisli Thor Axelsson - University of IcelandMatthew Moll - Brigham and Women's HospitalMichaela R. Anderson - Columbia University Medical CenterElana J. Bernstein - Columbia University Medical CenterRachel K. Putman - Brigham and Women's HospitalTomoyuki Hida - Kyushu UniversityHiroto Hatabu - Brigham and Women's HospitalEric A. Hoffman - Roy J. and Lucille A. Carver College of MedicineGanesh Raghu - University of Washington Medical CenterSteven M. Kawut - University of PennsylvaniaMargaret F. Doyle - University of VermontRussell Tracy - University of VermontLenore J. Launer - Institute on AgingAni Manichaikul - University of VirginiaStephen S. Rich - University of VirginiaDavid J. Lederer - RegeneronVilmundur Gudnason - Icelandic Heart AssociationBrian D. Hobbs - Brigham and Women's HospitalMichael H. Cho - Harvard UniversityGary M. Hunninghake - Brigham and Women's HospitalChristine Kim Garcia - Southwestern Medical CenterGunnar Gudmundsson - Landspitali University Hospital, Respiratory Medicine, Sleep and Allergy, Reykjavik, IcelandR. Graham Barr - Columbia UniversityAnna J. Podolanczuk - Weill Cornell Medical College, 12295, Department of Medicine, New York, New York, United States
- Resource Type
- Journal article
- Publication Details
- American journal of respiratory and critical care medicine, Vol.205(7), pp.795-805
- Publisher
- Amer Thoracic Soc
- DOI
- 10.1164/rccm.202108-1967OC
- PMID
- 34929108
- PMCID
- PMC10394677
- ISSN
- 1073-449X
- eISSN
- 1535-4970
- Number of pages
- 11
- Grant note
- name: University of Iceland Research Fund; name: University of Iceland Research Fund; name: University of Iceland Research Fund; name: University of Iceland Research Fund; DOI: 10.13039/100000049, name: National Institute on Aging, award: HHSN27120120022C, N01-AG-1-2100; DOI: 10.13039/100008184, name: COPD Foundation; name: Eimskip University Fund; DOI: 10.13039/100000069, name: National Institute of Arthritis and Musculoskeletal and Skin Diseases, award: K23-AR-075112; DOI: 10.13039/100006108, name: National Center for Advancing Translational Sciences, award: UL1-TR-000040, UL1-TR-001079, UL1-TR-001420; DOI: 10.13039/100004330, name: GlaxoSmithKline, award: SCO104960; name: Icelandic Research Fund, award: 141513-051; DOI: 10.13039/100000050, name: National Heart, Lung, and Blood Institute, award: HSN268201500003I, K08-HL136928, K23-HL-140087, K23-HL-140199, K23-HL-1502080, K23-HL-150301, K24-HL-103844, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, R01-HL077612, R01-HL093081, R01-HL111024, R01-HL130974, R01-HL135142, R01-HL137927, RC1-HL100543, T32-HL007427, U01-HL089856, U01-HL089897; name: Landspitali Scientific Fund, award: A-2019-029, A-2019-030, A-2020-017, A-2020-018, A2021-018
- Language
- English
- Date published
- 04/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984318714802771
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