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Associations of Pain Sensitivity and Conditioned Pain Modulation with Physical Activity: Findings from the Multicenter Osteoarthritis Study (MOST)
Journal article   Open access   Peer reviewed

Associations of Pain Sensitivity and Conditioned Pain Modulation with Physical Activity: Findings from the Multicenter Osteoarthritis Study (MOST)

Soyoung Lee, Tuhina Neogi, Brooke Mcginley, Na Wang, Laura Frey-Law, Kaveh A Torabian, Kosaku Aoyagi, Joshua J Stefanik, Lisa C Carlesso, Jeffrey M Hausdorff, …
Osteoarthritis and cartilage, Vol.32(8), pp.982-989
08/2024
DOI: 10.1016/j.joca.2024.04.020
PMCID: PMC11254545
PMID: 38763431
url
https://doi.org/10.1016/j.joca.2024.04.020View
Published (Version of record) Open Access

Abstract

Individuals with chronic pain due to knee osteoarthritis (OA) are insufficiently physically active, and alterations of facilitatory and inhibitory nociceptive signaling are common in this population. Our objective was to examine the association of these alterations in nociceptive signaling with objective accelerometer-based measures of physical activity in a large observational cohort. We used data from the Multicenter Osteoarthritis Study (MOST). Measures of peripheral and central pain sensitivity included pressure pain threshold (PPT) at the knee and mechanical temporal summation (TS) at the wrist, respectively. The presence of descending pain inhibition was assessed by conditioned pain modulation (CPM). Physical activity was quantitatively assessed over 7-days using a lower back-worn activity monitor. Summary metrics included steps/day, activity intensity, and sedentary time. Linear regression analyses were used to evaluate the association of pain sensitivity and the presence of descending pain inhibition with physical activity measures. Data from 1,873 participants was analyzed (55.9% female, age = 62.8±10.0 years). People having greater peripheral and central sensitivity showed lower step counts. CPM was not significantly related to any of the physical activity measures, and none of the exposures were significantly related to sedentary time. In this cohort, greater peripheral and central sensitivity were associated with reduced levels of objectively-assessed daily step counts. Further research may investigate ways to modify or treat heightened pain sensitivity as a means to increase physical activity in older adults with knee OA.
 step count sedentary time central sensitization pressure pain threshold knee osteoarthritis accelerometer

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