Journal article
Associations of Recipient Illness History With Hypertension and Diabetes After Living Kidney Donation
Transplantation, Vol.91(11), pp.1227-1232
06/15/2011
DOI: 10.1097/TP.0b013e31821a1ae2
PMID: 21499197
Abstract
Background. Little is known about associations of family health history with outcomes after kidney donation.
Methods. Using a database wherein Organ Procurement and Transplantation Network identifiers for 4650 living kidney donors in 1987 to 2007 were linked to administrative data of a US private health insurer (2000-2007 claims), we examined associations of recipient illness history as a measure of family history with postdonation diagnoses and drug-treatment for hypertension and diabetes. Cox regression with left and right censoring was applied to estimate associations (adjusted hazards ratios, aHR) of recipient illness history with postnephrectomy donor diagnoses, stratified by donor-recipient relationship.
Results. Recipient end-stage renal disease from hypertension, as compared with other recipient end-stage renal disease causes, was associated with modest, significant increases in the age- and gender-adjusted relative risks of hypertension diagnosis (aHR, 1.37%; 95% confidence interval [CI], 1.08-1.74) after donor nephrectomy among related donors. After adjustment for age, gender, and race, recipient type 2 diabetes compared with non-diabetic recipient status was associated with twice the relative risk of postdonation diabetes (aHR, 2.14; 95% CI, 1.28-3.55; P = 0.003) among related donors. These patterns were significant among white but not among non-white related donors. Recipient type 1 diabetes was associated with postdonation diabetes only in black related donors (aHR, 3.22; 95% CI, 1.04-9.98; P = 0.04). Recipient illness did not correlate significantly with outcomes in unrelated donors.
Conclusions. These data support a need for further study of family health history as a potential sociodemographic correlate of donor outcomes, including examination of potential mediating factors and variation in risk discrimination among donors of different racial groups.
Details
- Title: Subtitle
- Associations of Recipient Illness History With Hypertension and Diabetes After Living Kidney Donation
- Creators
- Krista L. Lentine - SalusMark A. Schnitzler - Saint Louis UniversityHuiling Xiao - Saint Louis UniversityConnie L. Davis - University of WashingtonDavid Axelrod - Dartmouth CollegeKevin C. Abbott - Walter Reed Army Institute of ResearchPaolo R. Salvalaggio - Saint Louis UniversityThomas E. Burroughs - Saint Louis UniversityGeorges Saab - Washington University in St. LouisDaniel C. Brennan - Washington University in St. Louis
- Resource Type
- Journal article
- Publication Details
- Transplantation, Vol.91(11), pp.1227-1232
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/TP.0b013e31821a1ae2
- PMID
- 21499197
- ISSN
- 0041-1337
- eISSN
- 1534-6080
- Number of pages
- 6
- Grant note
- K08DK073036 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) K08DK073036; P30DK079333 / National Institute of Diabetes Digestive and Kidney Diseases (NIDDK); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 06/15/2011
- Academic Unit
- Surgery
- Record Identifier
- 9984321865702771
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