Associations of body size with all-cause and cause-specific mortality in healthy older adults

Prudence R Carr; Katherine L Webb; Johannes T Neumann; Le T P Thao; Lawrence J Beilin; Michael E Ernst; Bernadette Fitzgibbon; Danijela Gasevic; Mark R Nelson; Anne B Newman; Suzanne G Orchard; Alice Owen; Christopher M Reid; Nigel P Stocks; Andrew M Tonkin; Robyn L Woods; John J McNeil

doi:10.1038/s41598-023-29586-w

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Associations of body size with all-cause and cause-specific mortality in healthy older adults

Journal article

Open access

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Associations of body size with all-cause and cause-specific mortality in healthy older adults

Prudence R Carr, Katherine L Webb, Johannes T Neumann, Le T P Thao, Lawrence J Beilin, Michael E Ernst, Bernadette Fitzgibbon, Danijela Gasevic, Mark R Nelson, Anne B Newman, …

Scientific reports, Vol.13(1), 3799

03/07/2023

DOI: 10.1038/s41598-023-29586-w

PMCID: PMC9992380

PMID: 36882434

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Abstract

In the general population, body mass index (BMI) and waist circumference are recognized risk factors for several chronic diseases and all-cause mortality. However, whether these associations are the same for older adults is less clear. The association of baseline BMI and waist circumference with all-cause and cause-specific mortality was investigated in 18,209 Australian and US participants (mean age: 75.1 ± 4.5 years) from the ASPirin in Reducing Events in the Elderly (ASPREE) study, followed up for a median of 6.9 years (IQR: 5.7, 8.0). There were substantially different relationships observed in men and women. In men, the lowest risk of all-cause and cardiovascular mortality was observed with a BMI in the range 25.0-29.9 kg/m [HR : 0.85; 95% CI, 0.73-1.00] while the highest risk was in those who were underweight [HR : 1.82; 95% CI 1.30-2.55], leading to a clear U-shaped relationship. In women, all-cause mortality was highest in those with the lowest BMI leading to a J-shaped relationship (HR : 1.64; 95% CI 1.26-2.14). Waist circumference showed a weaker relationship with all-cause mortality in both men and women. There was little evidence of a relationship between either index of body size and subsequent cancer mortality in men or women, while non-cardiovascular non-cancer mortality was higher in underweight participants. For older men, being overweight was found to be associated with a lower risk of all-cause mortality, while among both men and women, a BMI in the underweight category was associated with a higher risk. Waist circumference alone had little association with all-cause or cause-specific mortality risk.Trial registration ASPREE https://ClinicalTrials.gov number NCT01038583.

Aged

Aspirin

Australia - epidemiology

Body Size

Cause of Death

Female

Humans

Male

Thinness

Waist Circumference

Details

Title: Subtitle: Associations of body size with all-cause and cause-specific mortality in healthy older adults
Creators: Prudence R Carr - Australian Regenerative Medicine Institute
Katherine L Webb - Monash University
Johannes T Neumann - German Centre for Cardiovascular Research
Le T P Thao - Monash University
Lawrence J Beilin - The University of Western Australia
Michael E Ernst
Bernadette Fitzgibbon - Monash University
Danijela Gasevic - University of Edinburgh
Mark R Nelson - University of Tasmania
Anne B Newman - University of Pittsburgh
Suzanne G Orchard - Monash University
Alice Owen - Monash University
Christopher M Reid - Curtin University
Nigel P Stocks - The University of Adelaide
Andrew M Tonkin - Monash University
Robyn L Woods - Monash University
John J McNeil - Monash University
Resource Type: Journal article
Publication Details: Scientific reports, Vol.13(1), 3799
DOI: 10.1038/s41598-023-29586-w
PMID: 36882434
PMCID: PMC9992380
NLM abbreviation: Sci Rep
eISSN: 2045-2322
Grant note: NE 2165/1-1 / Deutsche Forschungsgemeinschaft 334047, 1127060 / National Health and Medical Research Council GNT 1136372 / National Health and Medical Research Council U01AG029824, U19AG062682 / NIH HHS
Language: English
Date published: 03/07/2023
Academic Unit: Family and Community Medicine; Pharmacy Practice and Science
Record Identifier: 9984375357402771

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