Journal article
Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use
European journal of nutrition, Vol.61(7), pp.3449-3459
10/01/2022
DOI: 10.1007/s00394-022-02899-8
PMCID: PMC10227860
PMID: 35583696
Abstract
We investigated the association of coffee and caffeine with breast cancer (BCa) risk, overall and by ER/PR status. We also examined potential interactions of coffee and caffeine with postmenopausal hormone use.
Our study included 77,688 postmenopausal participants from the Women's Health Initiative observational study cohort without a history of any cancer at baseline (except non-melanoma skin) and with valid Food Frequency Questionnaire data and complete data on dietary caffeine. Regular coffee (none, 1, 2-3, 4-5, and ≥ 6 cups/day) and caffeine (tertiles) were assessed at baseline. Information on BCa risk factors was collected at baseline. The associations were examined using survival analysis, accounting for death as a competing risk.
The median follow-up time for our cohort was 18.3 years. During the follow-up, 5005 women developed invasive breast cancer. In multivariable analysis, coffee was not associated with the overall invasive BCa risk. Higher caffeine intake was mildly associated with increased BCa risk (2nd vs. 1st tertile SHR = 1.10, 95% CI 1.03-1.18, 3rd vs. 1st tertile SHR-1.05, 95% CI 0.98-1.13, overall p = 0.03). We found no interaction of coffee/caffeine with postmenopausal hormone use (p interaction = 0.44 and 0.42, respectively). In the exploratory analysis by ER/PR status, we found a positive association of caffeine with ER+ /PR+ BCa (2nd vs. 1st tertile SHR = 1.17, 95% CI 1.07-1.28, 3rd vs. 1st tertile SHR = 1.13, 95% CI 1.03-1.24, overall p = 0.002); no associations were observed for ER-/PR- tumors. Coffee was not associated with the risk of ER+ /PR+ or ER-/PR- tumors.
We found no associations of coffee with BCa risk, overall and for ER/PR-defined tumor subtypes. The higher caffeine consumption was mildly and positively associated with the overall BCa risk and with ER+ /PR+ tumors.
Details
- Title: Subtitle
- Associations of coffee/caffeine consumption with postmenopausal breast cancer risk and their interactions with postmenopausal hormone use
- Creators
- Lusine Yaghjyan - Florida CollegeEric McLaughlin - The Ohio State UniversityAmy Lehman - The Ohio State UniversityMarian L Neuhouser - Fred Hutch Cancer CenterThomas Rohan - Albert Einstein College of MedicineDorothy S Lane - Stony Brook UniversityLinda Snetselaar - University of Iowa, Fraternal Order of Eagles Diabetes Research CenterElectra Paskett - The Ohio State University
- Resource Type
- Journal article
- Publication Details
- European journal of nutrition, Vol.61(7), pp.3449-3459
- DOI
- 10.1007/s00394-022-02899-8
- PMID
- 35583696
- PMCID
- PMC10227860
- NLM abbreviation
- Eur J Nutr
- ISSN
- 1436-6207
- eISSN
- 1436-6215
- Grant note
- K12 CA133250 / NCI NIH HHS K12CA133250 / NCI NIH HHS HHSN268201600003C / NHLBI NIH HHS HHSN268201600001C / NHLBI NIH HHS HHSN268201600004C / NIH HHS HHSN268201600003C / NIH HHS HHSN268201600018C / NHLBI NIH HHS K01CA21845701A1 / NCI NIH HHS HHSN268201600004C / NHLBI NIH HHS HHSN268201600002C / NHLBI NIH HHS HHSN268201600002C / NIH HHS K01HL142848 / NHLBI NIH HHS HHSN268201600001C / NIH HHS K01 HL142848 / NHLBI NIH HHS HHSN268201600018C / NIH HHS
- Language
- English
- Date published
- 10/01/2022
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984458060102771
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