Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype

Michelle M. Dunk; Jie Li; Simin Liu; Ramon Casanova; Jiu‐Chiuan Chen; Mark A. Espeland; Kathleen M. Hayden; JoAnn E. Manson; Stephen R. Rapp; Aladdin H. Shadyab; Linda G. Snetselaar; Linda Van Horn; Robert Wild; Ira Driscoll

doi:10.1002/alz.13358

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Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype

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Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype

Michelle M. Dunk, Jie Li, Simin Liu, Ramon Casanova, Jiu‐Chiuan Chen, Mark A. Espeland, Kathleen M. Hayden, JoAnn E. Manson, Stephen R. Rapp, Aladdin H. Shadyab, …

Alzheimer's & dementia, Vol.19(12), pp.5742-5754

12/2023

DOI: 10.1002/alz.13358

PMCID: PMC10784407

PMID: 37438877

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Abstract

INTRODUCTION Whether apolipoprotein E's (APOE’s) involvement in lipid metabolism contributes to Alzheimer's disease (AD) risk remains unknown. METHODS Incident probable dementia and cognitive impairment (probable dementia+mild cognitive impairment) were analyzed in relation to baseline serum lipids (total, low-density lipoprotein [LDL], high-density lipoprotein [HDL], non-HDL cholesterol, total-to-HDL, LDL-to-HDL, remnant cholesterol, and triglycerides) using Mendelian randomization in 5358 postmenopausal women from the Women's Health Initiative Memory Study. We also examined associations of baseline dietary cholesterol and fat with lipids based on APOE status. RESULTS After an average of 11.13 years, less favorable lipid levels related to greater dementia and cognitive impairment risk. Dementia (odds ratio [OR] = 3.13; 95% confidence interval [CI]: 2.31 to 4.24) and cognitive impairment (OR = 2.38; 95% CI: 1.85 to 3.06) risk were greatest in relation to higher remnant cholesterol levels. Greater cholesterol consumption related to poorer lipids in APOE4+ compared to APOE3 carriers. DISCUSSION APOE4+ carriers consuming more cholesterol had less favorable lipids, which were associated with greater dementia and cognitive impairment risk.

Details

Title: Subtitle: Associations of dietary cholesterol and fat, blood lipids, and risk for dementia in older women vary by APOE genotype
Creators: Michelle M. Dunk - Karolinska Institutet
Jie Li - Guangdong Academy of Medical Sciences
Simin Liu - Brown University
Ramon Casanova - Wake Forest University
Jiu‐Chiuan Chen - Departments of Population & Public Health Sciences and Neurology, Keck School of Medicine University of Southern California Los Angeles California USA
Mark A. Espeland - Wake Forest University
Kathleen M. Hayden - Wake Forest University
JoAnn E. Manson - Brigham and Women's Hospital
Stephen R. Rapp - Wake Forest University
Aladdin H. Shadyab - Human Longevity (United States)
Linda G. Snetselaar - University of Iowa
Linda Van Horn - Northwestern University
Robert Wild - University of Oklahoma Health Sciences Center
Ira Driscoll - University of Wisconsin–Milwaukee
Resource Type: Journal article
Publication Details: Alzheimer's & dementia, Vol.19(12), pp.5742-5754
DOI: 10.1002/alz.13358
PMID: 37438877
PMCID: PMC10784407
NLM abbreviation: Alzheimers Dement
ISSN: 1552-5260
eISSN: 1552-5279
Grant note: DOI: 10.13039/100000049, name: National Institute on Aging, award: HHSN‐271‐2011‐00004C, RF1AG079149, RF1AG074345
Language: English
Electronic publication date: 07/12/2023
Date published: 12/2023
Academic Unit: Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
Record Identifier: 9984445076902771

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