Journal article
Associations of fluoride intake with children's cortical bone mineral and strength measures at age 11
Journal of Public Health Dentistry, Vol.78(4), pp.352-359
2018
DOI: 10.1111/jphd.12286
PMCID: PMC6279557
PMID: 30155933
Abstract
Objectives There is strong affinity between fluoride and calcium, and mineralized tissues. Investigations of fluoride and bone health during childhood and adolescence show inconsistent results. This analysis assessed associations between period‐specific and cumulative fluoride intakes from birth to age 11, and age 11 cortical bone measures obtained using peripheral quantitative computed tomography (pQCT) of the radius and tibia (n = 424). Methods Participants were a cohort recruited from eight Iowa hospitals at birth. Fluoride intakes from water, other beverages, selected foods, dietary supplements, and dentifrice were recorded every 1.5–6 months using detailed questionnaires. Correlations between bone measures (cortical bone mineral content, density, area, and strength) and fluoride intake were determined in bivariate and multivariable analyses adjusting for Tanner stage, weight and height. Results The majority of associations were weak. For boys, only the positive associations between daily fluoride intakes for 0–3 years and radius and tibia bone mineral content were statistically significant. For girls, the negative correlations of recent daily fluoride intake per kg of body weight from 8.5 to 11 years with radius bone mineral content, area, and strength and tibia strength were statistically significant. No associations between cumulative daily fluoride intakes from birth to 11 years and bone measures were statistically significant. Conclusions In this cohort of 11‐year‐old children, mostly living in optimally fluoridated areas, life‐long fluoride intakes from combined sources were weakly associated with tibia and radius cortical pQCT measures.
Details
- Title: Subtitle
- Associations of fluoride intake with children's cortical bone mineral and strength measures at age 11
- Creators
- Steven M Levy - University of Iowa College of Public HealthJulie M Eichenberger-Gilmore - Iowa City Veterans Affairs Health Care SystemJohn J Warren - University of Iowa College of DentistryGolnaz Kavand - University of Iowa College of DentistryElena Letuchy - University of Iowa College of Public HealthBarbara Broffitt - University of Iowa College of DentistryTeresa A Marshall - University of Iowa College of DentistryTrudy L Burns - University of Iowa College of Public HealthKathy F Janz - University of Iowa College of Liberal Arts and SciencesCynthia Pauley - University of IowaJames C Torner - University of Iowa College of Public HealthKathy Phipps - Research Consultant
- Resource Type
- Journal article
- Publication Details
- Journal of Public Health Dentistry, Vol.78(4), pp.352-359
- DOI
- 10.1111/jphd.12286
- PMID
- 30155933
- PMCID
- PMC6279557
- NLM abbreviation
- J Public Health Dent
- ISSN
- 0022-4006
- eISSN
- 1752-7325
- Publisher
- John Wiley & Sons, Inc; Hoboken, USA
- Number of pages
- 8
- Grant note
- University of Iowa Dr. Levy's Wright–Bush–Shreves' Endowed Professor Fund US National Institutes of Health Department of Veterans Affairs policy (R01‐DE09551; R01‐DE12101; M01‐RR00059; UL1‐RR024979)
- Language
- English
- Date published
- 2018
- Academic Unit
- Preventive and Community Dentistry; Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery; Health, Sport, and Human Physiology
- Record Identifier
- 9983917660202771
Metrics
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