Journal article
Associations of menopausal vasomotor symptoms with fracture incidence
The journal of clinical endocrinology and metabolism, Vol.100(2), pp.524-534
02/2015
DOI: 10.1210/jc.2014-3062
PMCID: PMC4318890
PMID: 25522264
Abstract
Vasomotor symptoms (VMS) are common. Whether VMS are associated with fracture incidence or bone mineral density (BMD) levels is unknown.
This study aimed to examine associations of baseline VMS with fracture incidence and BMD.
This was a prospective observational study with mean (SD) followup of 8.2 (1.7) years (1993-2005).
Forty United States clinical centers.
We examined data from Women's Health Initiative Clinical Trial participants (n = 23 573) age 50-79 years not using menopausal hormone therapy, and 4,867 participants of the BMD sub-study.
None.
We measured baseline VMS, incident adjudicated fractures, and BMD (baseline, annual visits 1, 3, 6, and 9).
After adjustment for baseline age, body mass index, race/ethnicity, smoking, and education, the hazard ratio for hip fracture among women with baseline moderate/severe VMS (vs no VMS) was 1.78 (95% confidence interval [CI], 1.20-2.64; P = .01). There was no association between VMS and vertebral fracture. VMS severity was inversely associated with BMD during followup (P = .004 for femoral neck, P = .045 for lumbar spine). In repeated measures models, compared with women who reported no VMS, women with moderate/severe VMS had 0.015 g/cm(2) lower femoral neck BMD (95% CI, -0.025--0.005) and 0.016 g/cm(2) lower lumbar spine BMD (95% CI, -0.032--0.004).
Women with moderate/severe VMS have lower BMD and increased hip fracture rates. Elucidation of the biological mechanisms underlying these associations may inform the design of preventive strategies for at-risk women prior to occurrence of fracture.
Details
- Title: Subtitle
- Associations of menopausal vasomotor symptoms with fracture incidence
- Creators
- Carolyn J Crandall - University of California, Los AngelesAaron Aragaki - Women's Health InitiativeJane A Cauley - University of PittsburghJoAnn E Manson - Brigham and Women's HospitalErin LeBlanc - Kaiser Permanente Center for Health ResearchRobert Wallace - University of IowaJean Wactawski-Wende - State University of New YorkAndrea LaCroix - Fred Hutch Cancer CenterMary Jo O'Sullivan - University of MiamiMara Vitolins - Wake Forest UniversityNelson B Watts - Mercy Health
- Resource Type
- Journal article
- Publication Details
- The journal of clinical endocrinology and metabolism, Vol.100(2), pp.524-534
- DOI
- 10.1210/jc.2014-3062
- PMID
- 25522264
- PMCID
- PMC4318890
- NLM abbreviation
- J Clin Endocrinol Metab
- ISSN
- 0021-972X
- eISSN
- 1945-7197
- Grant note
- HHSN268201100002I / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100046C / PHS HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS HHSN271201100004C / PHS HHS HHSN268201100003C / PHS HHS HHSN268201100004C / WHI NIH HHS HHSN268201100046C / NHLBI NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100001I / NHLBI NIH HHS HHSN268201100004C / PHS HHS HHSN268201100002C / PHS HHS HHSN268201100003C / WHI NIH HHS HHSN268201100001C / PHS HHS
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Epidemiology; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9984363618702771
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