Journal article
Associations of obesity with antidiabetic medication use after living kidney donation: An analysis of linked national registry and pharmacy fill records
Clinical transplantation, Vol.33(10), pp.e13696-n/a
10/01/2019
DOI: 10.1111/ctr.13696
PMCID: PMC7153560
PMID: 31421057
Abstract
We examined a novel linkage of national US donor registry data with records from a pharmacy claims warehouse (2007-2016) to examine associations (adjusted hazard ratio, (LCL)aHR(UCL)) of post-donation fills of antidiabetic medications (ADM, insulin or non-insulin agents) with body mass index (BMI) at donation and other demographic and clinical factors. In 28 515 living kidney donors (LKDs), incidence of ADM use at 9 years rose in a graded manner with higher baseline BMI: underweight, 0.9%; normal weight, 2.1%; overweight, 3.5%; obese, 8.5%. Obesity was associated with higher risk of ADM use compared with normal BMI (aHR, (3.36)4.59(6.27)). Metformin was the most commonly used ADM and was filled more often by obese than by normal weight donors (9-year incidence, 6.87% vs 1.85%, aHR, (3.55)5.00(7.04)). Insulin use was uncommon and did not differ significantly by BMI. Among a subgroup with BMI data at the 1-year post-donation anniversary (n = 19 528), compared with stable BMI, BMI increase >0.5 kg/m(2) by year 1 was associated with increased risk of subsequent ADM use (aHR, (1.03)1.48(2.14,) P = .04). While this study did not assess the impact of donation on the development of obesity, these data support that among LKD, obesity is a strong correlate of ADM use.
Details
- Title: Subtitle
- Associations of obesity with antidiabetic medication use after living kidney donation: An analysis of linked national registry and pharmacy fill records
- Creators
- Krista L. Lentine - Saint Louis UniversityFarrukh M. Koraishy - Saint Louis UniversityNagaraju Sarabu - University Hospitals of ClevelandAbhijit S. Naik - University of MichiganNgan N. Lam - University of AlbertaAmit X. Garg - Western UniversityDavid Axelrod - University of IowaZidong Zhang - Saint Louis UniversityGregory P. Hess - Drexel UniversityBertram L. Kasiske - Hennepin County Medical CenterDorry L. Segev - Saint Louis UniversityMacey L. Henderson - University of BaltimoreAllan B. Massie - University of BaltimoreCourtenay M. Holscher - University of BaltimoreMark A. Schnitzler - Saint Louis University
- Resource Type
- Journal article
- Publication Details
- Clinical transplantation, Vol.33(10), pp.e13696-n/a
- DOI
- 10.1111/ctr.13696
- PMID
- 31421057
- PMCID
- PMC7153560
- NLM abbreviation
- Clin Transplant
- ISSN
- 0902-0063
- eISSN
- 1399-0012
- Publisher
- Wiley
- Number of pages
- 10
- Grant note
- KRESCENT New Investigator Award; Canadian Institutes of Health Research (CIHR) HHSH250201500009C / Hennepin Healthcare Research Institute (HHRI) (US Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation) US Government R01-DK096008 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) R01DK120551 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Surgery
- Record Identifier
- 9984321862102771
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