Associations of omega-3 Fatty Acids With Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults

John S. Kim; Brian T. Steffen; Anna J. Podolanczuk; Steven M. Kawut; Imre Noth; Ganesh Raghu; Erin D. Michos; Eric A. Hoffman; Gisli Thor Axelsson; Gunnar Gudmundsson; Vilmundur Gudnason; Elias F. Gudmundsson; Rachel A. Murphy; Josee Dupuis; Hanfei Xu; Ramachandran S. Vasan; George T. O'Connor; William S. Harris; Gary M. Hunninghake; R. Graham Barr; Michael Y. Tsai; David J. Lederer

doi:10.1093/aje/kwaa168

Back

Associations of omega-3 Fatty Acids With Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults

Journal article

Open access

Peer reviewed

Associations of omega-3 Fatty Acids With Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults

John S. Kim, Brian T. Steffen, Anna J. Podolanczuk, Steven M. Kawut, Imre Noth, Ganesh Raghu, Erin D. Michos, Eric A. Hoffman, Gisli Thor Axelsson, Gunnar Gudmundsson, …

American journal of epidemiology, Vol.190(1), pp.95-108

01/01/2021

DOI: 10.1093/aje/kwaa168

PMCID: PMC7784523

PMID: 32803215

Files and links (1)

url

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7784523View

Published (Version of record) Open Access

Abstract

Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, attenuates interstitial lung disease (ILD) in experimental models, but human studies are lacking. We examined associations of circulating levels of DHA and other polyunsaturated fatty acids with hospitalization and death due to ILD over 12 years in the Multi-Ethnic Study of Atherosclerosis (MESA; n = 6,573). We examined cross-sectional associations with CT lung abnormalities in MESA (2000-2012; n = 6,541), the Framingham Heart Study (2005-2011; n = 3,917), and the Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik) (2002-2006; n = 1,106). Polyunsaturated fatty acid levels were determined from fasting blood samples and extracted from plasma phospholipids (MESA and AGES-Reykjavik) or red blood cell membranes (Framingham Heart Study). Higher DHA levels were associated with a lower risk of hospitalization due to ILD (per standard-deviation increment, adjusted rate ratio = 0.69, 95% confidence interval (CI): 0.48, 0.99) and a lower rate of death due to ILD (per standard-deviation increment, adjusted hazard ratio = 0.68, 95% CI: 0.47, 0.98). Higher DHA was associated with fewer interstitial lung abnormalities on computed tomography (per natural log increment, pooled adjusted odds ratio = 0.65, 95% CI: 0.46, 0.91). Higher DHA levels were associated with a lower risk of hospitalization and death due to ILD and fewer lung abnormalities on computed tomography in a meta-analysis of data from population-based cohort studies.

Life Sciences & Biomedicine

Public, Environmental & Occupational Health

Science & Technology

Details

Title: Subtitle: Associations of omega-3 Fatty Acids With Interstitial Lung Disease and Lung Imaging Abnormalities Among Adults
Creators: John S. Kim - Harvard University
Brian T. Steffen - University of Minnesota
Anna J. Podolanczuk - Boston University
Steven M. Kawut - Boston University
Imre Noth - Boston University
Ganesh Raghu - University of British Columbia
Erin D. Michos - University of British Columbia
Eric A. Hoffman - Icelandic Heart Association
Gisli Thor Axelsson - Johns Hopkins University
Gunnar Gudmundsson - University of Washington
Vilmundur Gudnason - University of Pennsylvania
Elias F. Gudmundsson - Iceland Heart Assoc, Kopavogur, Iceland
Rachel A. Murphy - University of Minnesota‐Twin Cities
Josee Dupuis - University of Virginia
Hanfei Xu - Harvard University ,
Ramachandran S. Vasan - University of South Dakota
George T. O'Connor - Harvard University ,
William S. Harris - Boston University
Gary M. Hunninghake - Harvard University
R. Graham Barr - Harvard University
Michael Y. Tsai - University of British Columbia
David J. Lederer - Harvard University ,
Resource Type: Journal article
Publication Details: American journal of epidemiology, Vol.190(1), pp.95-108
Publisher: Oxford Univ Press
DOI: 10.1093/aje/kwaa168
PMID: 32803215
PMCID: PMC7784523
ISSN: 0002-9262
eISSN: 1476-6256
Number of pages: 14
Grant note: Althingi (Icelandic Parliament) Pulmonary Fibrosis Foundation Scholars Award 17644 / Michael Smith Foundation for Health Research NHLBI-N01-HC-25195; HHSN268201500001I; 75N92019D00031; N01-AG-1-2100; HHSN27120120022C / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 141513-051 / Icelandic Research Fund UL1-TR-000040; UL1-TR-001079; UL1-TR-001420 / National Center for Advancing Translational Sciences (NIH) NIA Intramural Research Program (NIH) 704735 / Canadian Cancer Society; Canadian Cancer Society (CCS) HHSN268201500003I; N01-HC-95159; N01-HC-95160; N01-HC-95161; N01-HC-95162; N01-HC-95163; N01-HC-95164; N01-HC-95165; N01-HC-95166; N01-HC-95167; N01-HC-95168; N01-HC-95169 / National Heart, Lung, and Blood Institute (NHLBI), US National Institutes of Health (NIH) Hjartavernd (Icelandic Heart Association) Jay and Louis Coffman Endowment from the Department of Medicine, Boston University School of Medicine Evans Medical Foundation R01-HL077612; R01-HL093081; RC1-HL100543; R01-HL-103676; T32-HL-105323; K24-HL-131937; K23-HL-140199; P01-HL114501; R01-HL-111024 / NHLBI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Office of Dietary Supplements (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Language: English
Date published: 01/01/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
Record Identifier: 9984318701602771

Metrics

19 Record Views

14 Times Cited - Web of Science

See more details