Journal article
Associations of parent–adolescent closeness with P3 amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder
Alcoholism, clinical and experimental research, Vol.47(1), pp.155-167
01/2023
DOI: 10.1111/acer.14973
PMCID: PMC10910630
PMID: 36680783
Abstract
Background
Parents impact their offspring's brain development, neurocognitive function, risk, and resilience for alcohol use disorder (AUD) via both genetic and socio-environmental factors. Individuals with AUD and their unaffected children manifest low parietal P3 amplitude and low frontal theta (FT) power, reflecting heritable neurocognitive deficits associated with AUD. Likewise, children who experience poor parenting tend to have atypical brain development and greater rates of alcohol problems. Conversely, positive parenting can be protective and critical for normative development of self-regulation, neurocognitive functioning and the neurobiological systems subserving them. Yet, the role of positive parenting in resiliency toward AUD is understudied and its association with neurocognitive functioning and behavioral vulnerability to AUD among high-risk offspring is less known. Using data from the Collaborative Study on the Genetics of Alcoholism prospective cohort (N = 1256, mean age [SD] = 19.25 [1.88]), we investigated the associations of closeness with mother and father during adolescence with offspring P3 amplitude, FT power, and binge drinking among high-risk offspring.
Methods
Self-reported closeness with mother and father between ages 12 and 17 and binge drinking were assessed using the Semi-Structured Assessment for the Genetics of Alcoholism. P3 amplitude and FT power were assessed in response to target stimuli using a Visual Oddball Task.
Results
Multivariate multiple regression analyses showed that closeness with father was associated with larger P3 amplitude (p = 0.002) and higher FT power (p = 0.01). Closeness with mother was associated with less binge drinking (p = 0.003). Among male offspring, closeness with father was associated with larger P3 amplitude, but among female offspring, closeness with mother was associated with less binge drinking. These associations remained statistically significant with father's and mothers' AUD symptoms, socioeconomic status, and offspring impulsivity in the model.
Conclusions
Among high-risk offspring, closeness with parents during adolescence may promote resilience for developing AUD and related neurocognitive deficits albeit with important sex differences.
Details
- Title: Subtitle
- Associations of parent–adolescent closeness with P3 amplitude, frontal theta, and binge drinking among offspring with high risk for alcohol use disorder
- Creators
- Gayathri Pandey - SUNY Downstate Health Sciences UniversitySally I‐Chun Kuo - Rutgers, The State University of New JerseyKristina A. Horne‐Osipenko - SUNY Downstate Health Sciences UniversityAshwini K. Pandey - SUNY Downstate Health Sciences UniversityChella Kamarajan - SUNY Downstate Health Sciences UniversityStacey Saenz de Viteri - SUNY Downstate Health Sciences UniversitySivan Kinreich - SUNY Downstate Health Sciences UniversityDavid B. Chorlian - SUNY Downstate Health Sciences UniversityWeipeng Kuang - SUNY Downstate Health Sciences UniversityMallory Stephenson - Rutgers, The State University of New JerseyJohn Kramer - University of IowaAndrey Anokhin - Washington University in St. LouisYong Zang - Indiana UniversitySamuel Kuperman - University of IowaVictor Hesselbrock - University of ConnecticutMarc Schuckit - University of California San DiegoDanielle Dick - Rutgers, The State University of New JerseyGrace Chan - University of ConnecticutVivia V. McCutcheon - Washington University in St. LouisKathleen K. Bucholz - Washington University in St. LouisHoward Edenberg - Indiana UniversityJacquelyn L. Meyers - SUNY Downstate Health Sciences UniversityBernice Porjesz - SUNY Downstate Health Sciences University
- Resource Type
- Journal article
- Publication Details
- Alcoholism, clinical and experimental research, Vol.47(1), pp.155-167
- DOI
- 10.1111/acer.14973
- PMID
- 36680783
- PMCID
- PMC10910630
- NLM abbreviation
- Alcohol Clin Exp Res
- ISSN
- 0145-6008
- eISSN
- 1530-0277
- Grant note
- DOI: 10.13039/100000027, name: National Institute on Alcohol Abuse and Alcoholism, award: U10 AA008401
- Language
- English
- Date published
- 01/2023
- Academic Unit
- Psychiatry
- Record Identifier
- 9984360123902771
Metrics
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