Journal article
Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens
Molecular biology reports, Vol.41(6), pp.3973-3979
06/01/2014
DOI: 10.1007/s11033-014-3265-8
PMID: 24566683
Abstract
The ghrelin (GHRL), ghrelin receptor (GHSR), and insulin-like growth factor 1 receptor (IGF1R) genes have crucial effects on body weight (BW), body weight gain (BWG), feed intake (FI), and feed conversion ratio (FCR) in many species. However, few studies on associations of GHRL, GHSR, and IGF1R with BWG, FI, and FCR have been reported in chickens. In this study, 16 SNPs in GHRL, GHSR, and IGF1R genes were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). The objective of this study was to examine the associations of GHRL, GHSR, and IGF1R genes polymorphisms with BW at 49 days (BW49) and 70 days (BW70) of age, BWG, FI, and FCR in the interval in two yellow meat-type populations with a total of 724 birds. The results showed that rs15675067 of GHRL was significantly associated with BW70, BWG, and FCR (P < 0.05). For GHSR, rs16675844 had significant effects on FI and FCR (P < 0.01), and that rs14678932 showed significant association with BWG and FI (P < 0.05). Rs14011780 of IGF1R was strongly associated with BW49, BW70, and FCR (P < 0.05). Furthermore, haplotypes based on three SNPs of rs14986828, rs15675067, and rs15675065 in GHRL were significantly associated with BW70 and FCR (P < 0.05). Meanwhile, a three-SNP haplotype comprising rs14011783, rs14011780, and rs14011776 in IGF1R showed significant effects on BW49, BW70, and FCR (P < 0.05). Therefore, it was concluded that the identified SNPs and analyzed haplotypes in this study might be useful for broiler breeding programs.
Details
- Title: Subtitle
- Associations of polymorphisms in GHRL, GHSR, and IGF1R genes with feed efficiency in chickens
- Creators
- Sihua Jin - China Agricultural UniversitySirui Chen - China Agricultural UniversityHuifeng Li - Shanxi Agricultural UniversityYue Lu - China Agricultural UniversityGuiyun Xu - China Agricultural UniversityNing Yang - China Agricultural University
- Resource Type
- Journal article
- Publication Details
- Molecular biology reports, Vol.41(6), pp.3973-3979
- DOI
- 10.1007/s11033-014-3265-8
- PMID
- 24566683
- NLM abbreviation
- Mol Biol Rep
- ISSN
- 0301-4851
- eISSN
- 1573-4978
- Publisher
- Springer Nature
- Number of pages
- 7
- Grant note
- 2012QJ096 / Chinese Universities Scientific Fund IRT0945; IRT1191 / Changjiang Scholars and Innovative Research in University of China 31201794; 31172203 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Language
- English
- Date published
- 06/01/2014
- Academic Unit
- Biochemistry and Molecular Biology
- Record Identifier
- 9985150206202771
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