Journal article
Associations of pulmonary microvascular blood volume with per cent emphysema and CT emphysema subtypes in the community: the MESA Lung study
Thorax, Vol.80(5), pp.309-317
05/2025
DOI: 10.1136/thorax-2024-222002
PMCID: PMC11999787
PMID: 39496494
Abstract
Background Pulmonary microvasculature alterations are implicated in emphysema pathogenesis, but the association between pulmonary microvascular blood volume (PMBV) and emphysema has not been directly assessed at scale, and prior studies have used non-specific measures of emphysema. Methods The Multi-Ethnic Study of Atherosclerosis Lung Study invited participants recruited from the community without renal impairment to undergo contrast-enhanced dual-energy CT. Pulmonary blood volume was calculated by material decomposition; PMBV was defined as blood volume in the peripheral 2 cm of the lung. Non-contrast CT was acquired to assess per cent emphysema and novel CT emphysema subtypes, which include the diffuse emphysema subtype and small-airways-related combined bronchitic-apical emphysema subtype. Generalised linear regression models included age, sex, race/ethnicity, body size, smoking, total lung volume and small airway count. Results Among 495 participants, 53% were never-smokers and the race/ethnic distribution was 35% white, 31% black, 15% Hispanic and 18% Asian. Mean PMBV was 352±120 mL; mean per cent emphysema was 4.95±4.75%. Lower PMBV was associated with greater per cent emphysema (−0.90% per 100 mL PMBV, 95% CI: −1.29 to –0.51). The association was of larger magnitude in participants with 10 or more pack-years smoking and airflow obstruction, but present among participants with no smoking history or airflow limitation, and was specific to the diffuse CT emphysema subtype (−1.48% per 100 mL PMBV, 95% CI: −2.31 to –0.55). Conclusion In this community-based study, lower PMBV was associated with greater per cent emphysema, including in participants without a smoking history or airflow limitation, and was specific to the diffuse CT emphysema subtype.
Details
- Title: Subtitle
- Associations of pulmonary microvascular blood volume with per cent emphysema and CT emphysema subtypes in the community: the MESA Lung study
- Creators
- Emilia A Hermann - Columbia University Irving Medical CenterAmin Motahari - University of Iowa, RadiologyEric A Hoffman - University of Iowa, RadiologyYifei Sun - Columbia University Irving Medical CenterNorrina Allen - Northwestern UniversityElsa D Angelini - Columbia UniversityAlain G Bertoni - Wake Forest UniversityDavid A Bluemke - University of Wisconsin–MadisonSarah E Gerard - University of IowaJunfeng Guo - University of Iowa, RadiologyDavid W Kaczka - University of IowaAndrew Laine - Columbia UniversityErin Michos - Johns Hopkins UniversityPrashant Nagpal - University of Wisconsin–MadisonJames S Pankow - University of MinnesotaCoralynn S Sack - University of WashingtonBenjamin Smith - Columbia UniversityKaren Hinckley Stukovsky - University of WashingtonKarol E Watson - University of California, Los AngelesArtur Wysoczanski - Columbia University Irving Medical CenterR Graham Barr - Columbia University Irving Medical Center
- Resource Type
- Journal article
- Publication Details
- Thorax, Vol.80(5), pp.309-317
- DOI
- 10.1136/thorax-2024-222002
- PMID
- 39496494
- PMCID
- PMC11999787
- NLM abbreviation
- Thorax
- ISSN
- 0040-6376
- eISSN
- 1468-3296
- Publisher
- BMJ PUBLISHING GROUP
- Grant note
- National Heart, Lung and Blood Institute: R01- HL077612, R01- HL121270, R01- HL155816- 02, R01- HL071759, R01- HL093081, 75N92020D00002, 75N92020D00001, 75N92020D00005, 75N92020D00003, 75N92020D00006, 75N92020D00004, 75N92020D00007, N01- HC- 95159, N01- HC- 95169
This research was supported by grants R01- HL077612, R01- HL121270, R01- HL155816- 02, R01- HL071759 and R01- HL093081 and contracts 75N92020D00002, 75N92020D00001, 75N92020D00005, 75N92020D00002, 75N92020D00003, 75N92020D00006, 75N92020D00004, 75N92020D00007, N01- HC- 95159 through N01- HC- 95169 from the National Heart, Lung and Blood Institute.
- Language
- English
- Electronic publication date
- 11/04/2024
- Date published
- 05/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Anesthesia; Internal Medicine
- Record Identifier
- 9984745458402771
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