Associations of white matter integrity and cortical thickness in patients with schizophrenia and healthy controls

Stefan Ehrlich; Daniel Geisler; Anastasia Yendiki; Patricia Panneck; Veit Roessner; Vince D Calhoun; Vincent A Magnotta; Randy L Gollub; Tonya White

doi:10.1093/schbul/sbt056

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Associations of white matter integrity and cortical thickness in patients with schizophrenia and healthy controls

Journal article

Open access

Peer reviewed

Associations of white matter integrity and cortical thickness in patients with schizophrenia and healthy controls

Stefan Ehrlich, Daniel Geisler, Anastasia Yendiki, Patricia Panneck, Veit Roessner, Vince D Calhoun, Vincent A Magnotta, Randy L Gollub and Tonya White

Schizophrenia bulletin, Vol.40(3), pp.665-674

05/2014

DOI: 10.1093/schbul/sbt056

PMCID: PMC3984509

PMID: 23661633

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Abstract

Typical brain development includes coordinated changes in both white matter (WM) integrity and cortical thickness (CT). These processes have been shown to be disrupted in schizophrenia, which is characterized by abnormalities in WM microstructure and by reduced CT. The aim of this study was to identify patterns of association between WM markers and cortex-wide CT in healthy controls (HCs) and patients with schizophrenia (SCZ). Using diffusion tensor imaging and structural magnetic resonance imaging data of the Mind Clinical Imaging Consortium study (130 HC and 111 SCZ), we tested for associations between (a) fractional anisotropy in selected manually labeled WM pathways (corpus callosum, anterior thalamic radiation, and superior longitudinal fasciculus) and CT, and (b) the number of lesion-like WM regions ("potholes") and CT. In HC, but not SCZ, we found highly significant negative associations between WM integrity and CT in several pathways, including frontal, temporal, and occipital brain regions. Conversely, in SCZ the number of WM potholes correlated with reduced CT in the left lateral temporal gyrus, left fusiform, and left lateral occipital brain area. Taken together, we found differential patterns of association between WM integrity and CT in HC and SCZ. Although the pattern in HC can be explained from a developmental perspective, the reduced gray matter CT in SCZ patients might be the result of focal but spatially heterogeneous disruptions of WM integrity.

Humans

Middle Aged

Cerebral Cortex - pathology

Male

Schizophrenia - pathology

Neural Pathways - pathology

Case-Control Studies

Diffusion Tensor Imaging

White Matter - pathology

Young Adult

Magnetic Resonance Imaging

Image Processing, Computer-Assisted

Nerve Fibers, Myelinated - pathology

Corpus Callosum - pathology

Adolescent

Adult

Female

Details

Title: Subtitle: Associations of white matter integrity and cortical thickness in patients with schizophrenia and healthy controls
Creators: Stefan Ehrlich - To whom correspondence should be addressed; Department of Child and Adolescent Psychiatry, Translational Developmental Neuroscience Section, Dresden University of Technology, University Hospital Carl Gustav Carus, Fetscherstraße 74, 01307 Dresden, Germany; tel: +49 351-458-2244, fax: +49 351-458-5754, e-mail: transden.lab@uniklinikum-dresden.de
Daniel Geisler
Anastasia Yendiki
Patricia Panneck
Veit Roessner
Vince D Calhoun
Vincent A Magnotta
Randy L Gollub
Tonya White
Resource Type: Journal article
Publication Details: Schizophrenia bulletin, Vol.40(3), pp.665-674
DOI: 10.1093/schbul/sbt056
PMID: 23661633
PMCID: PMC3984509
NLM abbreviation: Schizophr Bull
ISSN: 0586-7614
eISSN: 1745-1701
Publisher: United States
Grant note: K08-MH068540 / NIMH NIH HHS 1S10RR019307 / NCRR NIH HHS 1U24 RR021382A / NCRR NIH HHS UL1 RR025758 / NCRR NIH HHS U24RR021992-01 / NCRR NIH HHS P41RR14075 / NCRR NIH HHS K99/R00 EB008129 / NIBIB NIH HHS M01 RR025758-01 / NCRR NIH HHS 1S10RR023401 / NCRR NIH HHS 1S10RR023043 / NCRR NIH HHS
Language: English
Date published: 05/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984051566202771

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