Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala

Jason J Radley; Luke R Johnson; William G M Janssen; Jeremiah Martino; Raphael Lamprecht; Patrick R Hof; Joseph E LeDoux; John H Morrison

doi:10.1111/j.1460-9568.2006.04962.x

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Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala

Journal article

Peer reviewed

Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala

Jason J Radley, Luke R Johnson, William G M Janssen, Jeremiah Martino, Raphael Lamprecht, Patrick R Hof, Joseph E LeDoux and John H Morrison

The European journal of neuroscience, Vol.24(3), pp.876-884

08/2006

DOI: 10.1111/j.1460-9568.2006.04962.x

PMID: 16930415

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Abstract

Changes in dendritic spine number and shape are believed to reflect structural plasticity consequent to learning. Previous studies have strongly suggested that the dorsal subnucleus of the lateral amygdala is an important site of physiological plasticity in Pavlovian fear conditioning. In the present study, we examined the effect of auditory fear conditioning on dendritic spine numbers in the dorsal subnucleus of the lateral amygdala using an immunolabelling procedure to visualize the spine-associated protein spinophilin. Associatively conditioned rats that received paired tone and shock presentations had 35% more total spinophilin-immunoreactive spines than animals that had unpaired stimulation, consistent with the idea that changes in the number of dendritic spines occur during learning and account in part for memory.

Immunohistochemistry

Microscopy, Electron, Transmission

Electric Stimulation - adverse effects

Acoustic Stimulation

Conditioning (Psychology) - physiology

Amygdala - metabolism

Rats

Male

Synapses - ultrastructure

Dendritic Spines - metabolism

Avoidance Learning - physiology

Fear - physiology

Rats, Sprague-Dawley

Nerve Tissue Proteins - metabolism

Amygdala - ultrastructure

Animals

Neuronal Plasticity - physiology

Synapses - metabolism

Microfilament Proteins - metabolism

Dendritic Spines - ultrastructure

Memory - physiology

Details

Title: Subtitle: Associative Pavlovian conditioning leads to an increase in spinophilin-immunoreactive dendritic spines in the lateral amygdala
Creators: Jason J Radley - Laboratory for Neuronal Structure and Function, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. radley@salk.edu
Luke R Johnson
William G M Janssen
Jeremiah Martino
Raphael Lamprecht
Patrick R Hof
Joseph E LeDoux
John H Morrison
Resource Type: Journal article
Publication Details: The European journal of neuroscience, Vol.24(3), pp.876-884
Publisher: France
DOI: 10.1111/j.1460-9568.2006.04962.x
PMID: 16930415
ISSN: 0953-816X
eISSN: 1460-9568
Grant note: P50 MH58911 / NIMH NIH HHS
Language: English
Date published: 08/2006
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984070621602771

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