Associative plasticity in the medial auditory thalamus and cerebellar interpositus nucleus during eyeblink conditioning

Hunter E Halverson; Inah Lee; John H Freeman

doi:10.1523/JNEUROSCI.0208-10.2010

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Associative plasticity in the medial auditory thalamus and cerebellar interpositus nucleus during eyeblink conditioning

Journal article

Open access

Peer reviewed

Associative plasticity in the medial auditory thalamus and cerebellar interpositus nucleus during eyeblink conditioning

Hunter E Halverson, Inah Lee and John H Freeman

The Journal of neuroscience, Vol.30(26), pp.8787-8796

06/30/2010

DOI: 10.1523/JNEUROSCI.0208-10.2010

PMCID: PMC2914487

PMID: 20592200

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https://doi.org/10.1523/JNEUROSCI.0208-10.2010View

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Abstract

Eyeblink conditioning, a type of associative motor learning, requires the cerebellum. The medial auditory thalamus is a necessary source of stimulus input to the cerebellum during auditory eyeblink conditioning. Nothing is currently known about interactions between the thalamus and cerebellum during associative learning. In the current study, neuronal activity was recorded in the cerebellar interpositus nucleus and medial auditory thalamus simultaneously from multiple tetrodes during auditory eyeblink conditioning to examine the relative timing of learning-related plasticity within these interconnected areas. Learning-related changes in neuronal activity correlated with the eyeblink conditioned response were evident in the cerebellum before the medial auditory thalamus over the course of training and within conditioning trials, suggesting that thalamic plasticity may be driven by cerebellar feedback. Short-latency plasticity developed in the thalamus during the first conditioning session and may reflect attention to the conditioned stimulus. Extinction training resulted in a decrease in learning-related activity in both structures and an increase in inhibition within the cerebellum. A feedback projection from the cerebellar nuclei to the medial auditory thalamus was identified, which may play a role in learning by facilitating stimulus input to the cerebellum via the thalamo-pontine projection.

Microelectrodes

Rats, Long-Evans

Rats

Male

Auditory Perception - physiology

Neural Pathways - physiology

Association Learning - physiology

Action Potentials

Conditioning, Eyelid - physiology

Neural Inhibition - physiology

Animals

Neuronal Plasticity - physiology

Auditory Pathways - physiology

Time Factors

Thalamus - physiology

Cerebellar Nuclei - physiology

Feedback, Physiological - physiology

Models, Neurological

Extinction, Psychological - physiology

Details

Title: Subtitle: Associative plasticity in the medial auditory thalamus and cerebellar interpositus nucleus during eyeblink conditioning
Creators: Hunter E Halverson - Department of Psychology, University of Iowa, Iowa City, Iowa 52242, USA
Inah Lee
John H Freeman
Resource Type: Journal article
Publication Details: The Journal of neuroscience, Vol.30(26), pp.8787-8796
Publisher: United States
DOI: 10.1523/JNEUROSCI.0208-10.2010
PMID: 20592200
PMCID: PMC2914487
ISSN: 0270-6474
eISSN: 1529-2401
Grant note: R01 MH080005-03 / NIMH NIH HHS R01 MH080005 / NIMH NIH HHS R01 MH080005-04 / NIMH NIH HHS MH-080005 / NIMH NIH HHS
Language: English
Date published: 06/30/2010
Academic Unit: Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984065754502771

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