Journal article
Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study
Journal of allergy and clinical immunology, Vol.131(2), pp.361-368.e11
02/2013
DOI: 10.1016/j.jaci.2012.11.036
PMCID: PMC3564253
PMID: 23374265
Abstract
The potential consequences of asthma in childhood and young adulthood on lung structure in older adults have not been studied in a large, population-based cohort.
The authors hypothesized that a history of asthma onset in childhood (age 18 years or before) or young adulthood (age 19-45 years) was associated with altered lung structure on computed tomography in later life.
The Multi-Ethnic Study of Atherosclerosis Lung Study recruited 3965 participants and assessed asthma history by using standardized questionnaires, guideline-based spirometry, and segmental airway dimensions and percentage of low attenuation area (%LAA) on computed tomographic scans.
Asthma with onset in childhood and young adulthood was associated with large decrements in FEV1 among participants with a mean age of 66 years (−365 mL and −343 mL, respectively; P < .001). Asthma with onset in childhood and young adulthood was associated with increased mean airway wall thickness standardized to an internal perimeter of 10 mm (0.1 mm, P < .001 for both), predominantly from narrower segmental airway lumens (−0.39 mm and −0.34 mm, respectively; P < .001). Asthma with onset in childhood and young adulthood also was associated with a greater %LAA (1.69% and 4.30%, respectively; P < .001). Findings were similar among never smokers, except that differential %LAA in childhood-onset asthma were not seen in them.
Asthma with onset in childhood or young adulthood was associated with reduced lung function, narrower airways, and among asthmatic patients who smoked, greater %LAA in later life.
Details
- Title: Subtitle
- Asthma and lung structure on computed tomography: The Multi-Ethnic Study of Atherosclerosis Lung Study
- Creators
- Kathleen M Donohue - Columbia University, New York, NYEric A Hoffman - University of Iowa, Iowa City, IowaHeather Baumhauer - University of Iowa, Iowa City, IowaJunfeng Guo - University of Iowa, Iowa City, IowaFiras S Ahmed - Columbia University, New York, NYGina S Lovasi - Columbia University, New York, NYDavid R Jacobs - University of Minnesota, Minneapolis, MinnPaul Enright - University of Arizona, Tucson, ArizR. Graham Barr - Columbia University, New York, NY
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.131(2), pp.361-368.e11
- DOI
- 10.1016/j.jaci.2012.11.036
- PMID
- 23374265
- PMCID
- PMC3564253
- NLM abbreviation
- J Allergy Clin Immunol
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Publisher
- Mosby, Inc
- Grant note
- R01 HL077612, R01 HL075476, RC1 HL100543, and N01-HC95159-169 / National Institutes of Health University of Iowa National Institutes of Health (NIH) Boehringer Ingelheim Alpha One Foundation
- Language
- English
- Date published
- 02/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Internal Medicine
- Record Identifier
- 9984051584102771
Metrics
32 Record Views