Journal article
Astrocytes express functional chemokine receptors
Journal of neuroimmunology, Vol.111(1), pp.109-121
2000
DOI: 10.1016/S0165-5728(00)00371-4
PMID: 11063828
Abstract
Multiple lines of evidence are presented characterizing the functional expression of chemokine receptors CXCR4, CCR1, CCR5, and CX3CR1 on astrocytes. Most of these receptors are expressed at low levels and may only be detectable on a subset of cells during disease or following cytokine induction. The expression of CXCR2, CCR2, CCR3, CCR10, CCR11, and several orphan receptors associated with HIV-1 infection has also been proposed. The appearance of several chemokine receptors implies a wider role for chemokines in the regulation of central nervous system functions. Available evidence indicates that selected chemokines induce further chemokine synthesis in astrocytes providing a mechanism to amplify inflammatory responses in the central nervous system.
Details
- Title: Subtitle
- Astrocytes express functional chemokine receptors
- Creators
- Martin E Dorf - Harvard UniversityMichael A Berman - Harvard UniversityShigeyuki Tanabe - Harvard UniversityMichael Heesen - RWTH Aachen UniversityYi Luo - Harvard University
- Resource Type
- Journal article
- Publication Details
- Journal of neuroimmunology, Vol.111(1), pp.109-121
- Publisher
- Elsevier B.V
- DOI
- 10.1016/S0165-5728(00)00371-4
- PMID
- 11063828
- ISSN
- 0165-5728
- eISSN
- 1872-8421
- Language
- English
- Date published
- 2000
- Academic Unit
- Urology
- Record Identifier
- 9984319978002771
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