Journal article
Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
Neuron (Cambridge, Mass.), Vol.61(2), pp.213-219
2009
DOI: 10.1016/j.neuron.2008.11.024
PMCID: PMC2673052
PMID: 19186164
Abstract
Astrocytes modulate neuronal activity by releasing chemical transmitters via a process termed gliotransmission. The role of this process in the control of behavior is unknown. Since one outcome of SNARE-dependent gliotransmission is the regulation of extracellular adenosine and because adenosine promotes sleep, we genetically inhibited the release of gliotransmitters and asked if astrocytes play an unsuspected role in sleep regulation. Inhibiting gliotransmission attenuated the accumulation of sleep pressure, assessed by measuring the slow wave activity of the EEG during NREM sleep, and prevented cognitive deficits associated with sleep loss. Since the sleep-suppressing effects of the A1 receptor antagonist CPT were prevented following inhibition of gliotransmission and because intracerebroventricular delivery of CPT to wild-type mice mimicked the transgenic phenotype, we conclude that astrocytes modulate the accumulation of sleep pressure and its cognitive consequences through a pathway involving A1 receptors.
Details
- Title: Subtitle
- Astrocytic Modulation of Sleep Homeostasis and Cognitive Consequences of Sleep Loss
- Creators
- Michael M Halassa - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USACedrick Florian - Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USATommaso Fellin - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAJames R Munoz - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USASo-Young Lee - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USATed Abel - Department of Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAPhilip G Haydon - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USAMarcos G Frank - Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
- Resource Type
- Journal article
- Publication Details
- Neuron (Cambridge, Mass.), Vol.61(2), pp.213-219
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.neuron.2008.11.024
- PMID
- 19186164
- PMCID
- PMC2673052
- ISSN
- 0896-6273
- eISSN
- 1097-4199
- Language
- English
- Date published
- 2009
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065835302771
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