Journal article
Atenolol for ventricular ectopy: A dose‐response study
Clinical pharmacology and therapeutics, Vol.41(1), pp.118-123
01/1987
DOI: 10.1038/clpt.1987.20
PMID: 3802701
Abstract
The antiarrhythmic efficacy, safety, and tolerance of atenolol was evaluated in 32 patients with an average of at least 60 ventricular ectopic depolarizations/hr. Patients received, single‐blind, the following treatments for 2 weeks each: placebo and atenolol, 50, 100, and 200 mg daily. A 24‐hour ambulatory ECG recording was obtained each week. Reduction in ventricular ectopic frequency by at least 75% occurred in six of 32 patients receiving 50 mg daily, five of 30 patients receiving 100 mg daily, and three of 21 patients receiving 200 mg daily (P = not significant for any paired dose comparison). No patient who failed to respond to a lower dose responded to 200 mg daily. The frequency of ventricular tachycardia was reduced by at least 75% in eight of 17 patients receiving 50 mg daily, seven of 16 patients receiving 100 mg daily, and eight of 11 receiving 200 mg daily (P = not significant for any paired dose comparison). Atenolol was discontinued because of adverse effects in 12 patients. The results indicate that atenolol is more effective in suppressing ventricular tachycardia than in suppressing overall ventricular ectopy.
Clinical Pharmacology and Therapeutics (1987) 41, 118–123; doi:10.1038/clpt.1987.20
Details
- Title: Subtitle
- Atenolol for ventricular ectopy: A dose‐response study
- Creators
- Paul E Fenster - University of Oklahoma Health Sciences CenterDwight Reynolds - University of Oklahoma Health Sciences CenterLawrence D Horwitz - University of Oklahoma Health Sciences CenterDouglass Morrison - University of Oklahoma Health Sciences CenterSteven Goldman - University of Oklahoma Health Sciences CenterUdho Thadani - University of Oklahoma Health Sciences CenterRalph Lazzara - University of Oklahoma Health Sciences CenterRuth Serokman - University of Oklahoma Health Sciences CenterFrank I Marcus - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- Clinical pharmacology and therapeutics, Vol.41(1), pp.118-123
- DOI
- 10.1038/clpt.1987.20
- PMID
- 3802701
- ISSN
- 0009-9236
- eISSN
- 1532-6535
- Number of pages
- 6
- Grant note
- ICI Americas, Inc. Wilmington, Del. Flinn Foundation, Phoenix, Ariz.
- Language
- English
- Date published
- 01/1987
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656528902771
Metrics
12 Record Views