Atherosclerosis profile and incidence of cardiovascular events: a population-based survey

Jennifer G Robinson; Kathleen M Fox; Michael F Bullano; Susan Grandy; SHIELD Study Group

doi:10.1186/1471-2261-9-46

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Atherosclerosis profile and incidence of cardiovascular events: a population-based survey

Jennifer G Robinson, Kathleen M Fox, Michael F Bullano, Susan Grandy and SHIELD Study Group

BMC cardiovascular disorders, Vol.9(1), pp.46-46

09/15/2009

DOI: 10.1186/1471-2261-9-46

PMCID: PMC2753582

PMID: 19754940

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Abstract

Atherosclerosis is a chronic progressive disease often presenting as clinical cardiovascular disease (CVD) events. This study evaluated the characteristics of individuals with a diagnosis of atherosclerosis and estimated the incidence of CVD events to assist in the early identification of high-risk individuals. Respondents to the US SHIELD baseline survey were followed for 2 years to observe incident self-reported CVD. Respondents had subclinical atherosclerosis if they reported a diagnosis of narrow or blocked arteries/carotid artery disease without a past clinical CVD event (heart attack, stroke or revascularization). Characteristics of those with atherosclerosis and incident CVD were compared with those who did not report atherosclerosis at baseline but had CVD in the following 2 years using chi-square tests. Logistic regression model identified characteristics associated with atherosclerosis and incident events. Of 17,640 respondents, 488 (2.8%) reported having subclinical atherosclerosis at baseline. Subclinical atherosclerosis was associated with age, male gender, dyslipidemia, circulation problems, hypertension, past smoker, and a cholesterol test in past year (OR = 2.2) [all p < 0.05]. Incident CVD was twice as high in respondents with subclinical atherosclerosis (25.8%) as in those without atherosclerosis or clinical CVD (12.2%). In individuals with subclinical atherosclerosis, men (RR = 1.77, p = 0.050) and individuals with circulation problems (RR = 2.36, p = 0.003) were at greatest risk of experiencing CVD events in the next 2 years. Self-report of subclinical atherosclerosis identified an extremely high-risk group with a >25% risk of a CVD event in the next 2 years. These characteristics may be useful for identifying individuals for more aggressive diagnostic and therapeutic efforts.

Cardiovascular Diseases - etiology

United States - epidemiology

Cross-Sectional Studies

Risk Assessment

Cardiovascular Diseases - prevention & control

Humans

Middle Aged

Risk Factors

Atherosclerosis - complications

Logistic Models

Male

Atherosclerosis - epidemiology

Disease Progression

Incidence

Patient Selection

Atherosclerosis - therapy

Time Factors

Cardiovascular Diseases - epidemiology

Female

Aged

Odds Ratio

Longitudinal Studies

Population Surveillance

Details

Title: Subtitle: Atherosclerosis profile and incidence of cardiovascular events: a population-based survey
Creators: Jennifer G Robinson - Department of Medicine, University of Iowa, Iowa City, IA, USA. jennifer-g-robinson@uiowa.edu
Kathleen M Fox
Michael F Bullano
Susan Grandy
SHIELD Study Group
Resource Type: Journal article
Publication Details: BMC cardiovascular disorders, Vol.9(1), pp.46-46
DOI: 10.1186/1471-2261-9-46
PMID: 19754940
PMCID: PMC2753582
NLM abbreviation: BMC Cardiovasc Disord
ISSN: 1471-2261
eISSN: 1471-2261
Publisher: England
Language: English
Date published: 09/15/2009
Academic Unit: Epidemiology; Internal Medicine
Record Identifier: 9983995152102771

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