Journal article
Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology
The Journal of physiology, Vol.593(12), pp.2627-2634
06/15/2015
DOI: 10.1113/jphysiol.2014.287714
PMCID: PMC4500348
PMID: 25640301
Abstract
Unnatural amino acid incorporation into ion channels has proven to be a valuable approach to interrogate detailed hypotheses arising from atomic resolution structures. In this short review, we provide a brief overview of some of the basic principles and methods for incorporation of unnatural amino acids into proteins. We also review insights into the function and pharmacology of voltage-gated ion channels that have emerged from unnatural amino acid mutagenesis approaches.
Details
- Title: Subtitle
- Atom-by-atom engineering of voltage-gated ion channels: magnified insights into function and pharmacology
- Creators
- Stephan A Pless - Center for Biopharmaceuticals, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DenmarkRobin Y Kim - Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, BC, CanadaChristopher A Ahern - Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USAHarley T Kurata - Department of Anesthesiology, Pharmacology, and Therapeutics, University of British Columbia, Vancouver, BC, Canada
- Resource Type
- Journal article
- Publication Details
- The Journal of physiology, Vol.593(12), pp.2627-2634
- Publisher
- England
- DOI
- 10.1113/jphysiol.2014.287714
- PMID
- 25640301
- PMCID
- PMC4500348
- ISSN
- 0022-3751
- eISSN
- 1469-7793
- Grant note
- MOP-97988 / Canadian Institutes of Health Research GM106569 / NIGMS NIH HHS GM087519 / NIGMS NIH HHS R01 GM106569 / NIGMS NIH HHS
- Language
- English
- Date published
- 06/15/2015
- Academic Unit
- Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984065385002771
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