Atovaquone Compared with Dapsone for the Prevention of Pneumocystis carinii Pneumonia in Patients with HIV Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, or Both

Wafaa M El-Sadr; Robert L Murphy; Teresa McCabe Yurik; Roberta Luskin-Hawk; Tony W Cheung; Henry H Balfour; Robert Eng; Thomas M Hooton; Thomas M Kerkering; Malte Schutz; Charles van der Horst; Richard Hafner; Community Program for Clinical Research on AIDS and the AIDS Clinical Trials Group

doi:10.1056/NEJM199812243392604

Back

Atovaquone Compared with Dapsone for the Prevention of Pneumocystis carinii Pneumonia in Patients with HIV Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, or Both

Journal article

Peer reviewed

Atovaquone Compared with Dapsone for the Prevention of Pneumocystis carinii Pneumonia in Patients with HIV Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, or Both

Wafaa M El-Sadr, Robert L Murphy, Teresa McCabe Yurik, Roberta Luskin-Hawk, Tony W Cheung, Henry H Balfour, Robert Eng, Thomas M Hooton, Thomas M Kerkering, Malte Schutz, …

The New England journal of medicine, Vol.339(26), pp.1889-1895

12/24/1998

DOI: 10.1056/NEJM199812243392604

PMID: 9862944

View Online

Abstract

The prevention of Pneumocystis carinii pneumonia has had a substantial influence on the course of human immunodeficiency virus (HIV) disease. 1 , 2 Although trimethoprim–sulfamethoxazole is the treatment of choice for prophylaxis against P. carinii pneumonia, intolerance often limits its use and makes it necessary to use alternative regimens. 3 Dapsone, alone or in combination with pyrimethamine, is a commonly recommended prophylactic regimen for P. carinii pneumonia in patients who cannot tolerate trimethoprim–sulfamethoxazole. 4 Dapsone plus pyrimethamine has been shown to be superior to aerosolized pentamidine for the prevention of toxoplasmosis. 5 However, dapsone has limitations: it is less effective than trimethoprim–sulfamethoxazole for the prevention . . .

Details

Title: Subtitle: Atovaquone Compared with Dapsone for the Prevention of Pneumocystis carinii Pneumonia in Patients with HIV Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, or Both
Creators: Wafaa M El-Sadr
Robert L Murphy
Teresa McCabe Yurik
Roberta Luskin-Hawk
Tony W Cheung
Henry H Balfour
Robert Eng
Thomas M Hooton
Thomas M Kerkering
Malte Schutz
Charles van der Horst
Richard Hafner
Community Program for Clinical Research on AIDS and the AIDS Clinical Trials Group
Contributors: J T Stapleton (Contributor) - University of Iowa, Internal Medicine
Resource Type: Journal article
Publication Details: The New England journal of medicine, Vol.339(26), pp.1889-1895
DOI: 10.1056/NEJM199812243392604
PMID: 9862944
NLM abbreviation: N Engl J Med
ISSN: 0028-4793
eISSN: 1533-4406
Publisher: Massachusetts Medical Society
Language: English
Date published: 12/24/1998
Academic Unit: Microbiology and Immunology; Infectious Diseases; Internal Medicine
Record Identifier: 9984094538202771

Metrics

28 Record Views

123 Times Cited - Web of Science

See more details