Journal article
Atrial Fibrillation and Cancer: Bidirectional Relationship and Potential for Personalized Care
JACC. Clinical electrophysiology, Vol.12(1), pp.183-199
2026
DOI: 10.1016/j.jacep.2025.09.044
PMID: 41182206
Abstract
A bidirectional relationship between cancer and atrial fibrillation (AF) is well known. Although systemic inflammation and the effects of cancer treatment significantly increase the risk of AF in patients with cancer, new-onset AF has also been shown to independently predict the risk of active malignancy. With a continued growth in our understanding of the molecular pathogenesis of AF and with the advent of novel anticancer agents with unique cardiotoxic effects, there is a need to study if the management of AF in patients with cancer requires a more "personalized" approach rather than a generalized approach. The current review focuses on the application of "precision cardio-oncology" to the screening, diagnosis, and management of AF in patients with cancer through biomarkers, cardiac imaging, and personalized risk stratification. Through this review, we highlight the growing need to incorporate personalized interventions into clinical studies and analyze the feasibility of integrating these into the routine care of patients with cancer.
Details
- Title: Subtitle
- Atrial Fibrillation and Cancer: Bidirectional Relationship and Potential for Personalized Care
- Creators
- Udhayvir S Grewal - Emory UniversityStefano H Byer - University of IowaSidharth Mahajan - Loyola MedicineAakash R Sheth - University of Pittsburgh Medical CenterKavitha Beedupalli - Louisiana State University Health Sciences Center New OrleansMichael G Fradley - University of PennsylvaniaEric H Yang - University of California, Los AngelesAndrea M Russo - Cooper Medical School of Rowan UniversityAarti Asnani - Beth Israel Deaconess Medical CenterPaari Dominic - University of Iowa Hospitals and Clinics
- Resource Type
- Journal article
- Publication Details
- JACC. Clinical electrophysiology, Vol.12(1), pp.183-199
- DOI
- 10.1016/j.jacep.2025.09.044
- PMID
- 41182206
- NLM abbreviation
- JACC Clin Electrophysiol
- ISSN
- 2405-5018
- eISSN
- 2405-5018
- Publisher
- ELSEVIER
- Language
- English
- Electronic publication date
- 10/28/2025
- Date published
- 2026
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9985024254902771
Metrics
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