Journal article
Atrial fibrillation evolution and rhythm control strategy following left appendage closure: new insights from the prospective FLAAC registry
BMC cardiovascular disorders, Vol.21(1), pp.227-227
05/03/2021
DOI: 10.1186/s12872-021-01994-8
PMCID: PMC8091509
PMID: 33941095
Abstract
Background: Percutaneous left atrial appendage (LAA) closure is an alternative to oral anticoagulation (OAC) for atrial fibrillation (AF) patients with high thromboembolism risk, particularly with contraindications to OAC. The LAA itself could possess proarrhythmogenic properties. As patients undergoing LAA closure could be candidates for cardioversion or ablation, we aimed to evaluate AF disease progression following LAA closure and the outcome of patients undergoing a rhythm control strategy after the procedure.Methods: The prospective multicenter French Nationwide Observational LAA Closure Registry (FLAAC) comprises 33 French interventional cardiology departments. Patients were included if they fulfilled the following criteria: history of non-valvular AF, successful LAA closure and long-term ECG follow-up.Results: A total of 331 patients with successful LAA closure were enrolled in the study. Patients mean age was 75.4 ± 0.5 years. The study population was characterized by a high thromboembolic risk (CHA 2 DS 2 -VASc score: 4.5 ± 0.1) and frequent comorbidities. The median follow-up was 11.9 months. One hundred and nineteen (36.0%) patients were in sinus rhythm (SR) at baseline. Among SR patients, documented AF was observed in 16 (13.4%) patients whereas 15 (7.1%) patients in AF at baseline restored SR, at the end of follow up. Finally, only 13 patients (4%) underwent procedures to restore SR without complications during the follow-up.Conclusions: The vast majority of patients undergoing LAA closure have the same AF status at baseline and one year after the index procedure. During the follow-up, a very small proportion (4%) of our population underwent procedures to restore SR without complications whatever the post-procedural antithrombotic strategy was.
Details
- Title: Subtitle
- Atrial fibrillation evolution and rhythm control strategy following left appendage closure: new insights from the prospective FLAAC registry
- Creators
- Nicolas Lellouche - Hôpitaux Universitaires Henri-MondorRaphaele Arrouasse - Centre Hospitalier Universitaire Henri-MondorJulien Ternacle - Centre Hospitalier Universitaire Henri-MondorRomain Gallet - Centre Hospitalier Universitaire Henri-MondorJean-Sylvain Hermida - Centre Hospitalier Universitaire Amiens-PicardieDavid Hamon - Centre Hospitalier Universitaire Henri-MondorJean-Michel Juliard - Laboratoire de Recherche Vasculaire TranslationnelleJean Luc Pasquié - Physiologie et Médecine Expérimentale du Coeur et des MusclesTarvinder Dhanjal - University Hospital CoventryEmmanuel Teiger - Hôpitaux Universitaires Henri-MondorPhilippe Le Corvoisier - Institut Mondor de Recherche Biomédicale
- Resource Type
- Journal article
- Publication Details
- BMC cardiovascular disorders, Vol.21(1), pp.227-227
- Publisher
- BioMed Central
- DOI
- 10.1186/s12872-021-01994-8
- PMID
- 33941095
- PMCID
- PMC8091509
- ISSN
- 1471-2261
- eISSN
- 1471-2261
- Language
- English
- Date published
- 05/03/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984691515602771
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