Journal article
Atrial natriuretic factor inhibits maximal tubuloglomerular feedback response
The American journal of physiology, Vol.252(5 Pt 2), pp.F825-F828
05/01/1987
DOI: 10.1152/ajprenal.1987.252.5.F825
PMID: 2953251
Abstract
The effect of atrial natriuretic factor (ANF) on maximal tubuloglomerular feedback was assessed in 16 Munich-Wistar rats. When the loop of Henle was not perfused, ANF increased single nephron glomerular filtration rate (SNGFR) and stop-flow pressure (SFP) from 32 +/- 2 nl/min and 32 +/- 2 mmHg in the control period to 37 +/- 2 nl/min (P less than 0.05) and 40 +/- 2 mmHg (P less than 0.025) after ANF administration, respectively. Because ANF caused SFP to rise but did not significantly alter plasma protein concentration, the estimated glomerular capillary hydraulic pressure increased. Maximal tubuloglomerular feedback response (examined by increasing orthograde microperfusion of the loop from 0 to 50 nl/min) was significantly inhibited by ANF; changes in SNGFR and SFP during the control state, -9 +/- 2 nl/min and -9 +/- 1 mmHg, were reduced to -4 +/- 2 nl/min (P less than 0.05) and -5 +/- 1 mmHg (P less than 0.05), respectively, after ANF administration. In conclusion, the increase in SNGFR caused by ANF is associated with an increase in glomerular capillary hydraulic pressure and with a blunted maximal tubuloglomerular feedback response.
Details
- Title: Subtitle
- Atrial natriuretic factor inhibits maximal tubuloglomerular feedback response
- Creators
- Chou-Long Huang - University of California, San FranciscoMartin G Cogan - University of California, San Francisco
- Resource Type
- Journal article
- Publication Details
- The American journal of physiology, Vol.252(5 Pt 2), pp.F825-F828
- DOI
- 10.1152/ajprenal.1987.252.5.F825
- PMID
- 2953251
- NLM abbreviation
- Am J Physiol
- ISSN
- 0002-9513
- eISSN
- 2163-5773
- Language
- English
- Date published
- 05/01/1987
- Academic Unit
- Nephrology; Internal Medicine
- Record Identifier
- 9984359916802771
Metrics
18 Record Views