Journal article
Attempted Suicide in Bipolar Disorder Pedigrees: Evidence for Linkage to 2p12
Biological psychiatry (1969), Vol.61(5), pp.725-727
2007
DOI: 10.1016/j.biopsych.2006.05.014
PMID: 17046723
Abstract
We are interested in identifying susceptibility genes that predispose subjects to attempted suicide.
We conducted a secondary analysis of genome-wide linkage data from 162 bipolar pedigrees that incorporated attempted suicide as a clinical covariate.
The strongest covariate-based linkage signal was seen on 2p12 at marker D2S1777. The logarithm of odds (LOD) score at marker D2S1777 rose from 1.56 to 3.82 after inclusion of the suicide covariate, resulting in significant chromosome-wide empirically derived p-values for the overall linkage finding (p = .01) and for the change in LOD score after the inclusion of the covariate (p = .02).
The finding on chromosome 2 replicates results from two previous studies of attempted suicide in pedigrees with alcohol dependence and in pedigrees with recurrent early-onset depression. Combined, these three studies provide compelling evidence for a locus influencing attempted suicide on 2p12.
Details
- Title: Subtitle
- Attempted Suicide in Bipolar Disorder Pedigrees: Evidence for Linkage to 2p12
- Creators
- Virginia L Willour - Johns Hopkins University, Baltimore, MarylandPeter P Zandi - Bloomberg School of Public Health, The Johns Hopkins University, Department of Mental Health, Baltimore, MarylandJudith A Badner - University of Chicago, Chicago, IllinoisJo Steele - Genetic Basis of Mood & Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MarylandKuangyi Miao - Johns Hopkins University, Baltimore, MarylandVictor Lopez - Genetic Basis of Mood & Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MarylandDean F MacKinnon - Johns Hopkins University, Baltimore, MarylandFrancis M Mondimore - Johns Hopkins University, Baltimore, MarylandBarbara Schweizer - Johns Hopkins University, Baltimore, MarylandMelvin G McInnis - University of Michigan, Ann Arbor, MichiganErin B Miller - Johns Hopkins University, Baltimore, MarylandJ. Raymond DePaulo - Johns Hopkins University, Baltimore, MarylandElliot S Gershon - University of Chicago, Chicago, IllinoisFrancis J McMahon - Genetic Basis of Mood & Anxiety Disorders, National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MarylandJames B Potash - Johns Hopkins University, Baltimore, Maryland
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.61(5), pp.725-727
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.biopsych.2006.05.014
- PMID
- 17046723
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Language
- English
- Date published
- 2007
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984070389402771
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