Attention Enhances the Retrieval and Stability of Visuospatial and Olfactory Representations in the Dorsal Hippocampus

Isabel A. Muzzio; Liat Levita; Jayant Kulkarni; Joseph Monaco; Clifford Kentros; Matthew Stead; Larry F. Abbott; Eric R. Kandel

doi:10.1371/journal.pbio.1000140

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Attention Enhances the Retrieval and Stability of Visuospatial and Olfactory Representations in the Dorsal Hippocampus

Journal article

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Attention Enhances the Retrieval and Stability of Visuospatial and Olfactory Representations in the Dorsal Hippocampus

Isabel A. Muzzio, Liat Levita, Jayant Kulkarni, Joseph Monaco, Clifford Kentros, Matthew Stead, Larry F. Abbott and Eric R. Kandel

PLoS biology, Vol.7(6), pp.e1000140-e1000140

06/01/2009

DOI: 10.1371/journal.pbio.1000140

PMCID: PMC2696347

PMID: 19564903

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Abstract

A key question in the analysis of hippocampal memory relates to how attention modulates the encoding and long-term retrieval of spatial and nonspatial representations in this region. To address this question, we recorded from single cells over a period of 5 days in the CA1 region of the dorsal hippocampus while mice acquired one of two goal-oriented tasks. These tasks required the animals to find a hidden food reward by attending to either the visuospatial environment or a particular odor presented in shifting spatial locations. Attention to the visuospatial environment increased the stability of visuospatial representations and phase locking to gamma oscillations-a form of neuronal synchronization thought to underlie the attentional mechanism necessary for processing task-relevant information. Attention to a spatially shifting olfactory cue compromised the stability of place fields and increased the stability of reward-associated odor representations, which were most consistently retrieved during periods of sniffing and digging when animals were restricted to the cup locations. Together, these results suggest that attention selectively modulates the encoding and retrieval of hippocampal representations by enhancing physiological responses to task-relevant information.

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Details

Title: Subtitle: Attention Enhances the Retrieval and Stability of Visuospatial and Olfactory Representations in the Dorsal Hippocampus
Creators: Isabel A. Muzzio - Columbia University
Liat Levita - Columbia University
Jayant Kulkarni - Columbia University
Joseph Monaco - Columbia University
Clifford Kentros - University of Oregon
Matthew Stead - Mayo Clinic Rochester, MN
Larry F. Abbott - Columbia University
Eric R. Kandel - Columbia University
Resource Type: Journal article
Publication Details: PLoS biology, Vol.7(6), pp.e1000140-e1000140
DOI: 10.1371/journal.pbio.1000140
PMID: 19564903
PMCID: PMC2696347
NLM abbreviation: PLoS Biol
ISSN: 1545-7885
eISSN: 1545-7885
Publisher: Public Library Science
Number of pages: 20
Grant note: Mothers Foundation Genome Center Minority Fellowship Schwartz Private Foundation NARSAD Howard Hughes Medical Institute
Language: English
Date published: 06/01/2009
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984295025102771

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