Journal article
Attention deficit hyperactivity disorder and neurocognitive correlates after childhood stroke
Journal of the International Neuropsychological Society, Vol.9(6), pp.815-829
09/2003
DOI: 10.1017/S1355617703960012
PMID: 14632240
Abstract
We investigated the frequency and neurocognitive correlates of attention deficit hyperactivity disorder and traits of this disorder (ADHD/Traits) after childhood stroke and orthopedic diagnosis in medical controls. Twenty-nine children with focal stroke lesions and individually matched children with clubfoot or scoliosis were studied with standardized psychiatric, intellectual, academic, adaptive, executive, and motivation function assessments. Lifetime ADHD/Traits were significantly more common in stroke participants with no prestroke ADHD than in orthopedic controls (16/28 vs. 7/29; Fisher's Exact p < .02). Lifetime ADHD/Traits in the orthopedic controls occurred exclusively in males with clubfoot (7/13; 54%). Participants with current ADHD/Traits functioned significantly worse (p < .005) than participants without current ADHD/Traits on all outcome measures. Within the stroke group, current ADHD/Traits was associated with significantly lower verbal IQ and arithmetic achievement (p < .04), more nonperseverative errors (p < .005), and lower motivation (p < .004). A principal components analysis of selected outcome variables significantly associated with current ADHD/Traits revealed “impaired neurocognition” and “inattention-apathy” factors. The latter factor was a more consistent predictor of current ADHD/Traits in regression analyses. These findings suggest that inattention and apathy are core features of ADHD/Traits after childhood stroke. This association may provide clues towards the understanding of mechanisms underlying the syndrome. (JINS, 2003, 9, 815–829.)
Details
- Title: Subtitle
- Attention deficit hyperactivity disorder and neurocognitive correlates after childhood stroke
- Creators
- Jeffrey E Max - 1University of California, San Diego and Children's Hospital and Health Center, San Diego, CaliforniaKatherine Mathews - 2University of Iowa, Department of Pediatrics and Neurology, Iowa City, IowaFacundo F Manes - 3Raul Carrea Institute for Neurological Research—FLENI, Buenos Aires, ArgentinaBrigitte A.M Robertson - 4GlaxoSmithKline, Research Triangle Park, North CarolinaPeter T Fox - 5Research Imaging Center, University of Texas Health Science Center, San Antonio, TexasJack L Lancaster - 5Research Imaging Center, University of Texas Health Science Center, San Antonio, TexasAmy E Lansing - 6Children's Hospital and Health Center, Department of Psychiatry, San Diego, CaliforniaAmy Schatz - 6Children's Hospital and Health Center, Department of Psychiatry, San Diego, CaliforniaNicole Collings - 6Children's Hospital and Health Center, Department of Psychiatry, San Diego, California
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.9(6), pp.815-829
- Publisher
- Cambridge University Press; New York, USA
- DOI
- 10.1017/S1355617703960012
- PMID
- 14632240
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Number of pages
- 15
- Language
- English
- Date published
- 09/2003
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurology (Pediatrics)
- Record Identifier
- 9984020789802771
Metrics
36 Record Views