Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline

Nunzio Pomara; Robert Block; Sandra Demetriou; Franz Fucek; Michael Stanley; Samuel Gershon

doi:10.1007/BF00427955

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Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline

Journal article

Peer reviewed

Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline

Nunzio Pomara, Robert Block, Sandra Demetriou, Franz Fucek, Michael Stanley and Samuel Gershon

Psychopharmacology, Vol.80(2), pp.129-130

05/1983

DOI: 10.1007/BF00427955

PMID: 6410440

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Abstract

Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been shown to cause a decrease in the number of muscarinic receptors. Thus, the long-term use of cholinergic precursors could have some adverse effects on central cholinergic functioning.

Details

Title: Subtitle: Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline
Creators: Nunzio Pomara
Robert Block
Sandra Demetriou
Franz Fucek
Michael Stanley
Samuel Gershon
Resource Type: Journal article
Publication Details: Psychopharmacology, Vol.80(2), pp.129-130
DOI: 10.1007/BF00427955
PMID: 6410440
NLM abbreviation: Psychopharmacology (Berl)
ISSN: 0033-3158
eISSN: 1432-2072
Language: English
Date published: 05/1983
Academic Unit: Iowa Neuroscience Institute; Anesthesia
Record Identifier: 9984007184802771

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