Attributable mortality of nosocomial candidemia, revisited

Olafur Gudlaugsson; Shane Gillespie; Kathleen Lee; Jeff Vande Berg; Jianfang Hu; Shawn Messer; Loreen Herwaldt; Michael Pfaller; Daniel Diekema

doi:10.1086/378745

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Attributable mortality of nosocomial candidemia, revisited

Journal article

Open access

Peer reviewed

Attributable mortality of nosocomial candidemia, revisited

Olafur Gudlaugsson, Shane Gillespie, Kathleen Lee, Jeff Vande Berg, Jianfang Hu, Shawn Messer, Loreen Herwaldt, Michael Pfaller and Daniel Diekema

Clinical infectious diseases, Vol.37(9), pp.1172-1177

11/01/2003

DOI: 10.1086/378745

PMID: 14557960

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Abstract

We reexamined the attributable mortality of nosocomial candidemia 15 years after a retrospective cohort study performed at our hospital demonstrated an attributable mortality of 38%. For all episodes of nosocomial candidemia between 1 July 1997 and 30 June 2001, we matched control patients with case patients by age, sex, date of hospital admission, underlying disease(s), length of time at risk, and surgical procedure(s). We analyzed 108 matched pairs. There were no statistically significant differences in age, sex, underlying disease(s), time at risk, surgical procedure, or vital signs at admission between cases and controls. The crude mortality among case patients was 61% (66 of 108 patients), compared with 12% (13 of 108) among control patients, for an attributable mortality of 49% (95% CI, 38%-60%). Nosocomial candidemia is still associated with an extremely high crude and attributable mortality--much higher than that expected from underlying disease alone.

Antifungal Agents - pharmacology

Length of Stay

Fluconazole - pharmacology

Age Factors

Humans

Middle Aged

Cross Infection - mortality

Candidiasis - mortality

Male

Survival Rate

Fungemia - mortality

Microbial Sensitivity Tests

Candida - classification

Sex Factors

Female

Retrospective Studies

Candida - drug effects

Cohort Studies

Details

Title: Subtitle: Attributable mortality of nosocomial candidemia, revisited
Creators: Olafur Gudlaugsson - Department of Epidemiology, University of Iowa College of Public Health, Iowa City, USA
Shane Gillespie
Kathleen Lee
Jeff Vande Berg
Jianfang Hu
Shawn Messer
Loreen Herwaldt
Michael Pfaller
Daniel Diekema
Resource Type: Journal article
Publication Details: Clinical infectious diseases, Vol.37(9), pp.1172-1177
DOI: 10.1086/378745
PMID: 14557960
NLM abbreviation: Clin Infect Dis
ISSN: 1058-4838
eISSN: 1537-6591
Publisher: United States
Language: English
Date published: 11/01/2003
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983986257502771

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