Attrition of T Cell Memory: Selective Loss of LCMV Epitope–Specific Memory CD8 T Cells following Infections with Heterologous Viruses

Liisa K Selin; Meei Y Lin; Kristy A Kraemer; Drew M Pardoll; Jonathan P Schneck; Steven M Varga; Paul A Santolucito; Amelia K Pinto; Raymond M Welsh

doi:10.1016/S1074-7613(00)80147-8

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Attrition of T Cell Memory: Selective Loss of LCMV Epitope–Specific Memory CD8 T Cells following Infections with Heterologous Viruses

Journal article

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Attrition of T Cell Memory: Selective Loss of LCMV Epitope–Specific Memory CD8 T Cells following Infections with Heterologous Viruses

Liisa K Selin, Meei Y Lin, Kristy A Kraemer, Drew M Pardoll, Jonathan P Schneck, Steven M Varga, Paul A Santolucito, Amelia K Pinto and Raymond M Welsh

Immunity (Cambridge, Mass.), Vol.11(6), pp.733-742

1999

DOI: 10.1016/S1074-7613(00)80147-8

PMID: 10626895

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Abstract

Using a variety of techniques, including limiting dilution assays (LDA), intracellular IFNγ assays, and D b-IgG1 MHC dimer staining to measure viral peptide-specific T cell number and function, we show here that heterologous virus infections quantitatively delete and qualitatively alter the memory pool of T cells specific to a previously encountered virus. We also show that a prior history of a virus infection can alter the hierarchy of the immunodominant peptide response to a second virus and that virus infections selectively reactivate memory T cells with distinct specificities to earlier viruses. These results are consistent with a model for the immune system that accommodates memory T cell populations for multiple pathogens over the course of a lifetime.

Details

Title: Subtitle: Attrition of T Cell Memory: Selective Loss of LCMV Epitope–Specific Memory CD8 T Cells following Infections with Heterologous Viruses
Creators: Liisa K Selin - Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Meei Y Lin - Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Kristy A Kraemer - Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Drew M Pardoll - Department of Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Jonathan P Schneck - Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
Steven M Varga - Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Paul A Santolucito - Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Amelia K Pinto - Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Raymond M Welsh - Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Resource Type: Journal article
Publication Details: Immunity (Cambridge, Mass.), Vol.11(6), pp.733-742
Publisher: Elsevier Inc
DOI: 10.1016/S1074-7613(00)80147-8
PMID: 10626895
ISSN: 1074-7613
eISSN: 1097-4180
Language: English
Date published: 1999
Academic Unit: Graduate College Admin and Gen; Microbiology and Immunology; Pathology
Record Identifier: 9984083210602771

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