Journal article
Atypical American visceral leishmaniasis caused by disseminated Leishmania amazonensis infection presenting with hepatitis and adenopathy
Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol.100(1), pp.79-82
2006
DOI: 10.1016/j.trstmh.2005.06.025
PMID: 16198385
Abstract
Leishmania amazonensis is widely recognised as a cause of cutaneous leishmaniasis in Latin America, but it can also disseminate to produce atypical visceral leishmaniasis with hepatitis and lymphadenopathy. The patient, an 8-year-old Brazilian boy, presented with a febrile illness and hepatosplenomegaly, elevated liver enzymes and generalised adenopathy. Serological tests using antigens of
L. chagasi, the typical cause of visceral leishmaniasis in Latin America, were inconclusive.
Leishmania amazonensis was eventually isolated in a culture of a lymph node. The patient recovered fully after treatment with meglumine antimoniate. As this case illustrates,
L. amazonensis produces a spectrum of disease that includes atypical American visceral leishmaniasis with evidence of hepatocellular injury and generalised lymphadenopathy.
Details
- Title: Subtitle
- Atypical American visceral leishmaniasis caused by disseminated Leishmania amazonensis infection presenting with hepatitis and adenopathy
- Creators
- J.A Aleixo - Department of Biochemistry, Universidade Federal do Rio Grande do Norte, CP 1624, Natal, RN, 59072-970, BrazilE.T Nascimento - Department of Biochemistry, Universidade Federal do Rio Grande do Norte, CP 1624, Natal, RN, 59072-970, BrazilG.R Monteiro - Department of Biochemistry, Universidade Federal do Rio Grande do Norte, CP 1624, Natal, RN, 59072-970, BrazilM.Z Fernandes - Department of Pediatrics, Universidade Federal do Rio Grande do Norte, Natal, RN, BrazilA.M.O Ramos - Department of Biochemistry, Universidade Federal do Rio Grande do Norte, CP 1624, Natal, RN, 59072-970, BrazilM.E Wilson - Departments of Internal Medicine, Biostatistics, Epidemiology, and Microbiology, University of Iowa, Iowa City, IA, USAR.D Pearson - Departments of Internal Medicine and Pathology, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, VA, USAS.M.B Jeronimo - Department of Biochemistry, Universidade Federal do Rio Grande do Norte, CP 1624, Natal, RN, 59072-970, Brazil
- Resource Type
- Journal article
- Publication Details
- Transactions of the Royal Society of Tropical Medicine and Hygiene, Vol.100(1), pp.79-82
- Publisher
- Elsevier Ltd
- DOI
- 10.1016/j.trstmh.2005.06.025
- PMID
- 16198385
- ISSN
- 0035-9203
- eISSN
- 1878-3503
- Language
- English
- Date published
- 2006
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984001202402771
Metrics
28 Record Views