Journal article
Atypical aHUS: State of the art
Molecular immunology, Vol.67(1), pp.31-42
09/2015
DOI: 10.1016/j.molimm.2015.03.246
PMID: 25843230
Abstract
Tremendous advances in our understanding of the thrombotic microangiopathies (TMAs) have revealed distinct disease mechanisms within this heterogeneous group of diseases. As a direct result of this knowledge, both children and adults with complement-mediated TMA now enjoy higher expectations for long-term health. In this update on atypical hemolytic uremic syndrome, we review the clinical characteristics; the genetic and acquired drivers of disease; the broad spectrum of environmental triggers; and current diagnosis and treatment options. Many questions remain to be addressed if additional improvements in patient care and outcome are to be achieved in the coming decade.
Details
- Title: Subtitle
- Atypical aHUS: State of the art
- Creators
- Carla M Nester - Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Division of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USAThomas Barbour - Centre for Complement and Inflammation Research, Department of Medicine, Imperial College, London W12 0NN, UKSantiago Rodriquez de Cordoba - Centro Investigaciones Biológicas and Ciber de Enfermedades Raras, Ramiro de Maeztu 9, 28040 Madrid, SpainMarie Agnes Dragon-Durey - Assistance Publique - Hopitaux de Paris, Service d'Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, FranceVeronique Fremeaux-Bacchi - Assistance Publique - Hopitaux de Paris, Service d'Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, FranceTim H J Goodship - Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, UKDavid Kavanagh - Assistance Publique - Hopitaux de Paris, Service d'Immunologie Biologique, Hopital Europeen Georges Pompidou, Paris, FranceMarina Noris - IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", Clinical Research Center for Rare Diseases "Aldo e Cele Daccò", Ranica, Bergamo, ItalyMatthew Pickering - Centre for Complement and Inflammation Research, Department of Medicine, Imperial College, London W12 0NN, UKPilar Sanchez-Corral - Unidad de Investigación and Ciber de Enfermedades Raras, Hospital Universitario de La Paz_IdiPAZ, Paseo de la Castellana 261, 28046 Madrid, SpainChristine Skerka - Leibniz Institute for Natural Product Research and Infection Biology, Jena, GermanyPeter Zipfel - Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany; Friedrich Schiller University, Jena, GermanyRichard J H Smith - Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, University of Iowa, Iowa City, IA, USA; Division of Nephrology, Stead Family Department of Pediatrics, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, USA. Electronic address: richard-smith@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Molecular immunology, Vol.67(1), pp.31-42
- DOI
- 10.1016/j.molimm.2015.03.246
- PMID
- 25843230
- NLM abbreviation
- Mol Immunol
- ISSN
- 0161-5890
- eISSN
- 1872-9142
- Publisher
- England
- Language
- English
- Date published
- 09/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006359102771
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