Journal article
Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement
Kidney international, Vol.83(2), pp.293-299
02/2013
DOI: 10.1038/ki.2012.384
PMID: 23235567
Abstract
Postinfectious glomerulonephritis is a common disorder that develops following an infection. In the majority of cases, there is complete recovery of renal function within a few days to weeks following resolution of the infection. In a small percentage of patients, however, the glomerulonephritis takes longer to resolve, resulting in persistent hematuria and proteinuria, or even progression to end-stage kidney disease. In some cases of persistent hematuria and proteinuria, kidney biopsies show findings of a postinfectious glomerulonephritis even in the absence of any evidence of a preceding infection. The cause of such ‘atypical’ postinfectious glomerulonephritis, with or without evidence of preceding infection, is unknown. Here we show that most patients diagnosed with this ‘atypical’ postinfectious glomerulonephritis have an underlying defect in the regulation of the alternative pathway of complement. These defects include mutations in complement-regulating proteins and antibodies to the C3 convertase known as C3 nephritic factors. As a result, the activated alternative pathway is not brought under control even after resolution of the infection. Hence, the sequela is continual glomerular deposition of complement factors with resultant inflammation and development of an ‘atypical’ postinfectious glomerulonephritis.
Details
- Title: Subtitle
- Atypical postinfectious glomerulonephritis is associated with abnormalities in the alternative pathway of complement
- Creators
- Sanjeev Sethi - Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USAFernando C Fervenza - Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USAYuzhou Zhang - Division of Nephrology, Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, Iowa City, Iowa, USALadan Zand - Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USANicole C Meyer - Division of Nephrology, Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, Iowa City, Iowa, USANicolò Borsa - Division of Nephrology, Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, Iowa City, Iowa, USASamih H Nasr - Division of Anatomic Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USARichard J H Smith - Division of Nephrology, Molecular Otolaryngology and Renal Research Laboratories, Carver College of Medicine, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Kidney international, Vol.83(2), pp.293-299
- DOI
- 10.1038/ki.2012.384
- PMID
- 23235567
- NLM abbreviation
- Kidney Int
- ISSN
- 0085-2538
- eISSN
- 1523-1755
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 02/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
- Record Identifier
- 9984006439002771
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