Audiology findings in patients with teprotumumab associated otologic symptoms

Caroline Y Yu; Tatiana Correa; Brittany A Simmons; Marlan R Hansen; Erin M Shriver

doi:10.1016/j.ajoc.2021.101202

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Audiology findings in patients with teprotumumab associated otologic symptoms

Journal article

Open access

Peer reviewed

Audiology findings in patients with teprotumumab associated otologic symptoms

Caroline Y Yu, Tatiana Correa, Brittany A Simmons, Marlan R Hansen and Erin M Shriver

American journal of ophthalmology case reports, Vol.24, p.101202

12/2021

DOI: 10.1016/j.ajoc.2021.101202

PMCID: PMC8452766

PMID: 34585021

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https://doi.org/10.1016/j.ajoc.2021.101202View

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Abstract

To report a case series of subjective and objective hearing function changes associated with teprotumumab treatment for thyroid eye disease. A 74-year-old female with a history of Graves' disease with thyroid eye disease was treated with teprotumumab. She had a history of bilateral tinnitus and noticed a subjective improvement in her tinnitus after the second infusion. Audiology testing obtained before, during, and after completion of infusions showed symmetric and rapidly progressive worsening of the patient's sensorineural hearing loss. In contrast, a 42-year-old male with a history of Grave's disease endorsed worsening intermittent tinnitus and low-pitched hearing loss after initiation of teprotumumab. Audiology testing before, during, and after completion of infusions showed stable and normal hearing function bilaterally. This case series highlights the importance of objective testing in patients prior to and after teprotumumab initiation as subjective hearing changes may not accurately reflect objective hearing function. In addition, this report suggests that teprotumumab may play a role in potentiating sensorineural hearing loss.

Grave's orbitopathy

Hearing

Sensorineural hearing loss

Teprotumumab

Thyroid eye disease (TED)

Details

Title: Subtitle: Audiology findings in patients with teprotumumab associated otologic symptoms
Creators: Caroline Y Yu - University of Iowa Hospitals and Clinics
Tatiana Correa - University of Iowa Hospitals and Clinics
Brittany A Simmons - University of Iowa Hospitals and Clinics
Marlan R Hansen - University of Iowa Hospitals and Clinics
Erin M Shriver - University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: American journal of ophthalmology case reports, Vol.24, p.101202
DOI: 10.1016/j.ajoc.2021.101202
PMID: 34585021
PMCID: PMC8452766
NLM abbreviation: Am J Ophthalmol Case Rep
ISSN: 2451-9936
eISSN: 2451-9936
Publisher: Elsevier Inc
Language: English
Date published: 12/2021
Academic Unit: Molecular Physiology and Biophysics; Neurosurgery; Otolaryngology; Ophthalmology and Visual Sciences
Record Identifier: 9984187027102771

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