Journal article
Audioprofile Surfaces: The 21st Century Audiogram
Annals of otology, rhinology & laryngology, Vol.125(5), pp.361-368
05/2016
DOI: 10.1177/0003489415614863
PMCID: PMC4821702
PMID: 26530094
Abstract
To present audiometric data in 3 dimensions by considering age as an addition dimension. Audioprofile surfaces (APSs) were fitted to a set of audiograms by plotting each measurement of an audiogram as an independent point in 3 dimensions with the x, y, and z axes representing frequency, hearing loss in dB, and age, respectively. Using the Java-based APS viewer as a standalone application, APSs were pre-computed for 34 loci. By selecting APSs for the appropriate genetic locus, a clinician can compare this APS-generated average surface to a specific patient's audiogram. Audioprofile surfaces provide an easily interpreted visual representation of a person's hearing acuity relative to others with the same genetic cause of hearing loss. Audioprofile surfaces will support the generation and testing of sophisticated hypotheses to further refine our understanding of the biology of hearing.
Details
- Title: Subtitle
- Audioprofile Surfaces: The 21st Century Audiogram
- Creators
- Kyle R Taylor - University of IowaKevin T Booth - Department of Otolaryngology, Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAHela Azaiez - Department of Otolaryngology, Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAChristina M Sloan - Department of Molecular Physiology and Biophysics, University of Iowa Carver, Iowa City, Iowa, USADiana L Kolbe - Department of Otolaryngology, Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAEmily N Glanz - University of IowaA Eliot Shearer - Department of Otolaryngology, Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAAdam P DeLuca - Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, Iowa, USAV Nikhil Anand - Center for Bioinformatics and Computational Biology, University of Iowa, Iowa City, Iowa, USAMichael S Hildebrand - Department of Otolaryngology, Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USAAllen C Simpson - Department of Otolaryngology, Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USARobert W Eppsteiner - Department of Otolaryngology, Head and Neck Surgery, University of Iowa, Iowa City, Iowa, USATodd E Scheetz - University of IowaTerry A Braun - University of IowaPatrick L M Huygen - Department of Otorhinolaryngology, Radboud University Nijmegen Medical Centre, Nijmegen, The NetherlandsRichard J H Smith - University of IowaThomas L Casavant - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Annals of otology, rhinology & laryngology, Vol.125(5), pp.361-368
- DOI
- 10.1177/0003489415614863
- PMID
- 26530094
- PMCID
- PMC4821702
- NLM abbreviation
- Ann Otol Rhinol Laryngol
- ISSN
- 0003-4894
- eISSN
- 1943-572X
- Publisher
- United States
- Grant note
- DC012049 / NIDCD NIH HHS F30 DC011674 / NIDCD NIH HHS R01 DC003544 / NIDCD NIH HHS R01 DC012049 / NIDCD NIH HHS DC011674 / NIDCD NIH HHS
- Language
- English
- Date published
- 05/2016
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Electrical and Computer Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Center for Bioinformatics and Computational Biology; Otolaryngology; Internal Medicine; Ophthalmology and Visual Sciences; Iowa Institute of Human Genetics
- Record Identifier
- 9983980071102771
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