Journal article
Augmentation of Blood Flow through Cerebral Collaterals by Inhibition of Nitric Oxide Synthase
Journal of cerebral blood flow and metabolism, Vol.14(5), pp.704-714
06/29/2016
DOI: 10.1038/jcbfm.1994.91
PMID: 7520451
Abstract
We examined the influence of nitric oxide (NO) on normal and collateral cerebral blood flow after occlusion of the middle cerebral artery (MCA). Effects of NG-nitro-l-arginine (nitroarginine), an inhibitor of NO synthase, were examined during normotension and hypotension (arterial pressure, 50 mm Hg) in 49 anesthetized dogs. Following a craniotomy, a branch of the MCA was cannulated, and collateral-dependent tissue was identified using the shadow-flow technique. Regional cerebral blood flow was measured with microspheres, and pial artery pressure was measured with a micropipette. Intravenous nitroarginine reduced blood flow to normal cerebrum by approximately 40% (p < 0.05) during normotension and hypotension, with aortic pressure maintained constant after nitroarginine administration. Injection of nitroarginine during hypotension, without control of pressor effects, increased aortic and pial artery pressure approximately twofold. Concurrently, blood flow to normal cerebrum decreased (p < 0.05), while flow to collateral-dependent cerebrum increased (p < 0.05). Phenylephrine was infused during hypotension to increase arterial pressure to values similar to those achieved following nitroarginine. Blood flow to collateral-dependent cerebrum increased (p < 0.05), but flow to normal cerebrum was not altered during infusion of phenylephrine. Thus, inhibition of NO synthase during hypotension increases arterial pressure, decreases blood flow to normal cerebrum, and increases blood flow to collateral-dependent cerebrum. Phenylephrine also increases perfusion pressure and blood flow to collateral-dependent cerebrum, but in contrast to nitroarginine, it does not redistribute blood flow from normal cerebrum.
Details
- Title: Subtitle
- Augmentation of Blood Flow through Cerebral Collaterals by Inhibition of Nitric Oxide Synthase
- Creators
- Michael G MuhonenDonald D Heistad - Departments of Internal Medicine and Pharmacology, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, U.S.AFrank M Faraci - Departments of Internal Medicine and Pharmacology, University of Iowa College of Medicine and Veterans Affairs Medical Center, Iowa City, Iowa, U.S.AChristopher M Loftus
- Resource Type
- Journal article
- Publication Details
- Journal of cerebral blood flow and metabolism, Vol.14(5), pp.704-714
- DOI
- 10.1038/jcbfm.1994.91
- PMID
- 7520451
- ISSN
- 0271-678X
- eISSN
- 1559-7016
- Language
- English
- Date published
- 06/29/2016
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040571902771
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