Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective

Ghassan S Kassab; Gary An; Edward A Sander; Michael I Miga; Julius M Guccione; Songbai Ji; Yoram Vodovotz

doi:10.1007/s10439-016-1596-4

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Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective

Journal article

Peer reviewed

Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective

Ghassan S Kassab, Gary An, Edward A Sander, Michael I Miga, Julius M Guccione, Songbai Ji and Yoram Vodovotz

Annals of biomedical engineering, Vol.44(9), pp.2611-2625

09/2016

DOI: 10.1007/s10439-016-1596-4

PMCID: PMC4983470

PMID: 27015816

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Abstract

In this era of tremendous technological capabilities and increased focus on improving clinical outcomes, decreasing costs, and increasing precision, there is a need for a more quantitative approach to the field of surgery. Multiscale computational modeling has the potential to bridge the gap to the emerging paradigms of Precision Medicine and Translational Systems Biology, in which quantitative metrics and data guide patient care through improved stratification, diagnosis, and therapy. Achievements by multiple groups have demonstrated the potential for (1) multiscale computational modeling, at a biological level, of diseases treated with surgery and the surgical procedure process at the level of the individual and the population; along with (2) patient-specific, computationally-enabled surgical planning, delivery, and guidance and robotically-augmented manipulation. In this perspective article, we discuss these concepts, and cite emerging examples from the fields of trauma, wound healing, and cardiac surgery.

Wound Healing

Cardiac Surgical Procedures

Wounds and Injuries

Computer Simulation

Humans

Translational Medical Research

Patient-Specific Modeling

Precision Medicine

Details

Title: Subtitle: Augmenting Surgery via Multi-scale Modeling and Translational Systems Biology in the Era of Precision Medicine: A Multidisciplinary Perspective
Creators: Ghassan S Kassab - California Medical Innovations Institute, San Diego, CA, 92121, USA
Gary An - Department of Surgery, University of Chicago, Chicago, IL, 60637, USA
Edward A Sander - Department of Biomedical Engineering, University of Iowa, Iowa City, IA, 52242, USA
Michael I Miga - Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, 37235, USA
Julius M Guccione - Department of Surgery, University of California, San Francisco, CA, 94143, USA
Songbai Ji - Department of Surgery and of Orthopaedic Surgery, Geisel School of Medicine, Dartmouth College, Hanover, NH, 03755, USA
Yoram Vodovotz - Center for Inflammation and Regenerative Modeling, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, 15219, USA. vodovotzy@upmc.edu
Resource Type: Journal article
Publication Details: Annals of biomedical engineering, Vol.44(9), pp.2611-2625
DOI: 10.1007/s10439-016-1596-4
PMID: 27015816
PMCID: PMC4983470
NLM abbreviation: Ann Biomed Eng
ISSN: 0090-6964
eISSN: 1573-9686
Publisher: United States
Grant note: R01 HL077921 / NHLBI NIH HHS P30 DK042086 / NIDDK NIH HHS KL2 TR001088 / NCATS NIH HHS R21 NS087796 / NINDS NIH HHS R01 HL118627 / NHLBI NIH HHS P50 GM053789 / NIGMS NIH HHS R21 NS078607 / NINDS NIH HHS R01 NS049251 / NINDS NIH HHS U01 HL119578 / NHLBI NIH HHS R01 GM107231 / NIGMS NIH HHS R01 NS092853 / NINDS NIH HHS R21 NS088781 / NINDS NIH HHS R01 GM115839 / NIGMS NIH HHS U01 DK072146 / NIDDK NIH HHS R01 CA162477 / NCI NIH HHS
Language: English
Date published: 09/2016
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center; Chemical and Biochemical Engineering
Record Identifier: 9984064213402771

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