Journal article
Aurea mediocritas: the importance of a balanced genome
Cold Spring Harbor perspectives in biology, Vol.6(11), pp.a015842-20
09/18/2014
DOI: 10.1101/cshperspect.a015842
PMCID: PMC4413234
PMID: 25237130
Abstract
Aneuploidy, defined as an abnormal number of chromosomes, is a hallmark of cancer. Paradoxically, aneuploidy generally has a negative impact on cell growth and fitness in nontransformed cells. In this work, we review recent progress in identifying how aneuploidy leads to genomic and chromosomal instability, how cells can adapt to the deleterious effects of aneuploidy, and how aneuploidy contributes to tumorigenesis in different genetic contexts. Finally, we also discuss how aneuploidy might be a target for anticancer therapies.
Details
- Title: Subtitle
- Aurea mediocritas: the importance of a balanced genome
- Creators
- Gianluca Varetti - Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115David Pellman - Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115 Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115 Howard Hughes Medical Institute, Chevy Chase, Maryland 20815-6789David J Gordon - Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115
- Resource Type
- Journal article
- Publication Details
- Cold Spring Harbor perspectives in biology, Vol.6(11), pp.a015842-20
- DOI
- 10.1101/cshperspect.a015842
- PMID
- 25237130
- PMCID
- PMC4413234
- ISSN
- 1943-0264
- eISSN
- 1943-0264
- Language
- English
- Date published
- 09/18/2014
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984093463902771
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