Journal article
Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example
Environmental science and pollution research international, Vol.25(17), pp.16508-16521
06/2018
DOI: 10.1007/s11356-017-1162-0
PMCID: PMC6015536
PMID: 29322390
Abstract
Toxicological studies use "specialty chemicals" and, thus, should assess and report both identity and degree of purity (homogeneity) of the chemicals (or toxicants) under investigation to ensure that other scientists can replicate experimental results. Although detailed reporting criteria for the synthesis and characterization of organic compounds have been established by organic chemistry journals, such criteria are inconsistently applied to the chemicals used in toxicological studies. Biologically active trace impurities may lead to incorrect conclusions about the chemical entity responsible for a biological response, which in turn may confound risk assessment. Based on our experience with the synthesis of PCBs and their metabolites, we herein propose guidelines for the "authentication" of synthetic PCBs and, by extension, other organic toxicants, and provide a checklist for documenting the authentication of toxicants reported in the peer-reviewed literature. The objective is to expand guidelines proposed for different types of biomedical and preclinical studies to include a thorough authentication of specialty chemicals, such as PCBs and their derivatives, with the goal of ensuring transparent and open reporting of scientific results in toxicology and the environmental health sciences.
Details
- Title: Subtitle
- Authentication of synthetic environmental contaminants and their (bio)transformation products in toxicology: polychlorinated biphenyls as an example
- Creators
- Xueshu Li - Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA, USAErika B Holland - Department of Biological Sciences, California State University of Long Beach, Long Beach, CA, USAWei Feng - Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USAJing Zheng - Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USAYao Dong - Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USAIsaac N Pessah - Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA, USAMichael W Duffel - Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA, USALarry W Robertson - Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA, USAHans-Joachim Lehmler - Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, Iowa City, IA, USA. hans-joachim-lehmler@uiowa.edu
- Resource Type
- Journal article
- Publication Details
- Environmental science and pollution research international, Vol.25(17), pp.16508-16521
- DOI
- 10.1007/s11356-017-1162-0
- PMID
- 29322390
- PMCID
- PMC6015536
- NLM abbreviation
- Environ Sci Pollut Res Int
- ISSN
- 1614-7499
- eISSN
- 1614-7499
- Publisher
- Germany
- Grant note
- ES011269 / National Institute of Environmental Health Sciences P30 ES005605 / NIEHS NIH HHS ES014901 / National Institute of Environmental Health Sciences R56 ES014901 / NIEHS NIH HHS R01 ES017425 / NIEHS NIH HHS P42 ES013661 / NIEHS NIH HHS P01 ES011269 / NIEHS NIH HHS P42 ES004699 / NIEHS NIH HHS ES013661 / National Institute of Environmental Health Sciences P30 CA086862 / NCI NIH HHS ES017425 / National Institute of Environmental Health Sciences ES004699 / National Institute of Environmental Health Sciences ES005605 / National Institute of Environmental Health Sciences R01 ES014901 / NIEHS NIH HHS
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute; Pharmaceutical Sciences and Experimental Therapeutics; Iowa Superfund Research Program; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984002489602771
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