Journal article
Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark
Pediatric research, Vol.67(3), pp.274-279
03/2010
DOI: 10.1203/PDR.0b013e3181cbd564
PMCID: PMC2909840
PMID: 19952865
Abstract
The objective of this study was to determine whether IgG and IgM autoantibodies to folate receptor alpha (FRalpha) in pregnant women are associated with an increased risk of oral cleft-affected offspring. A case-control study nested in the prospective Danish National Birth Cohort (100,418 pregnancies, enrolled during 1997-2003) was done. Hundred eighty-five children were born with an oral cleft. Maternal serum from their mothers (cases) was compared with maternal serum from 779 randomly selected mothers of nonmalformed children (controls). We found that the average level of FRalpha IgG autoantibodies did not differ significantly among cases and controls (p = 0.71). Slightly higher levels of FRalpha IgM autoantibodies were found among controls compared with cases. This was, however, not statistically significant (p = 0.06), except for mothers of children with isolated cleft lip (p = 0.04). Blocking of folate binding to FR was similar among cases and controls (p = 0.54). The results did not change when stratifying into the cleft subgroups, nor when only isolated oral cleft cases were considered. In conclusion, high maternal autoantibody levels and blocking of folate binding to FRalpha in maternal serum during pregnancy are not associated with an increased risk of oral clefts in the offspring in this population-based cohort.
Details
- Title: Subtitle
- Autoantibodies to folate receptor alpha during early pregnancy and risk of oral clefts in Denmark
- Creators
- Camilla Bille - Division of epidemiology, University of Southern Denmark, Odense C, Denmark. cbille@health.sdu.dkDorthe Almind PedersenAnne-Marie Nybo AndersenMaria A MansillaJeffrey C MurrayKaare ChristensenJohnathan L BallardElizabeth B GormanRobert M CabreraRichard H Finnell
- Resource Type
- Journal article
- Publication Details
- Pediatric research, Vol.67(3), pp.274-279
- DOI
- 10.1203/PDR.0b013e3181cbd564
- PMID
- 19952865
- PMCID
- PMC2909840
- NLM abbreviation
- Pediatr Res
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- Publisher
- United States
- Grant note
- DE016315 / NIDCR NIH HHS R01 DE008559 / NIDCR NIH HHS R37 DE008559 / NIDCR NIH HHS DE08559 / NIDCR NIH HHS R01 DE011948 / NIDCR NIH HHS DE11948 / NIDCR NIH HHS R01 DE016315-05 / NIDCR NIH HHS R01 DE011948-07 / NIDCR NIH HHS R01 DE011948-02 / NIDCR NIH HHS R01 DE016315 / NIDCR NIH HHS R01 DE008559-14 / NIDCR NIH HHS
- Language
- English
- Date published
- 03/2010
- Academic Unit
- Anatomy and Cell Biology; Stead Family Department of Pediatrics; Epidemiology; Pediatric Dentistry; Craniofacial Anomalies Research Center; Dental Research; Iowa Institute of Human Genetics
- Record Identifier
- 9984025338002771
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